ArticleDevelopment and psychopathology2017
Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months.
Article in Development and psychopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03434457 (Maternal Adversity, Vulnerability and Neurodevelopment), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Adversity, Vulnerability and Neurodevelopment
Who cites it
21 citing papers in PubMed, 84 citations in OpenAlex.
- Perceived connectedness during the perinatal period: Implications for parent and child well-being.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2026Review
- Advances in Perinatal Depression: A Focus on Screening and Treatment.Journal of clinical medicine · 2026Review
- Interaction between Risk Single-Nucleotide Polymorphisms of Developmental Dyslexia and Parental Education on Reading Ability: Evidence for Differential Susceptibility Theory.Behavioral sciences (Basel, Switzerland) · 2024Article
- Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life.Frontiers in nutrition · 2024Article
- Associations between mother's depressive symptoms during pregnancy and newborn's brain functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Prenatal programming of environmental sensitivity.Translational psychiatry · 2023Review
- An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia.Endocrine connections · 2023Review
- Differential effects of prenatal psychological distress and positive mental health on offspring socioemotional development from infancy to adolescence: a meta-analysis.Frontiers in pediatrics · 2023Review
- Article
- The DREAM BIG project as a model for harmonizing early measures of parental care and parent-child interactions across epidemiological cohorts.Frontiers in child and adolescent psychiatry · 2023Article
- Maternal prenatal psychological distress and vitamin intake with children's neurocognitive development.Pediatric research · 2022Article
- Parenting in the Context of the Child: Genetic and Social Processes.Monographs of the Society for Research in Child Development · 2022Article
- A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.Molecular psychiatry · 2022Review
- Inhibitory Control Mediates the Associations Between Parenting Practices and Depressive Symptoms in Adolescents: The Moderating Role of Catechol-O-Methyltransferase (COMT) Gene.Journal of youth and adolescence · 2021Article
- Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth.Pediatric research · 2021Article
- Gaining a deeper understanding of social determinants of preterm birth by integrating multi-omics data.Pediatric research · 2021Review
- Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward.Molecular neurobiology · 2020Article
- Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health.Psychoneuroendocrinology · 2019Review
- Associations of Prenatal and Postnatal Maternal Depressive Symptoms with Offspring Cognition and Behavior in Mid-Childhood: A Prospective Cohort Study.International journal of environmental research and public health · 2019Article
- Prenatal stress and enhanced developmental plasticity.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
Abstract
Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother-infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire-Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis-stress model at 36 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.