ArticleCurrent biology : CB2016
Automatic Segmentation of Drosophila Neural Compartments Using GAL4 Expression Data Reveals Novel Visual Pathways.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A connectome and analysis of the adulteLife · 2020Pooled it
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- Visual circuitry for distance estimation in Drosophila.Current biology : CB · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inJournal of neurophysiology · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inbioRxiv : the preprint server for biology · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
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- Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila.Nature communications · 2025Article
- Mating proximity blinds threat perception.Nature · 2024Article
- Connectome-driven neural inventory of a complete visual system.bioRxiv : the preprint server for biology · 2024Article
- Octopaminergic descending neurons inHeliyon · 2024Article
- Morphology and synapse topography optimize linear encoding of synapse numbers inbioRxiv : the preprint server for biology · 2024Article
- Biased cell adhesion organizes a circuit for visual motion integration.bioRxiv : the preprint server for biology · 2023Article
- Connectomic reconstruction predicts the functional organization of visual inputs to the navigation center of thebioRxiv : the preprint server for biology · 2023Article
- GABAergic signaling shapes multiple aspects ofiScience · 2023Article
- Hierarchical Modular Structure of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- Optic flow based spatial vision in insects.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Identifying distinct anatomical structures within the brain and developing genetic tools to target them are fundamental steps for understanding brain function. We hypothesize that enhancer expression patterns can be used to automatically identify functional units such as neuropils and fiber tracts. We used two recent, genome-scale Drosophila GAL4 libraries and associated confocal image datasets to segment large brain regions into smaller subvolumes. Our results (available at https://strawlab.org/braincode) support this hypothesis because regions with well-known anatomy, namely the antennal lobes and central complex, were automatically segmented into familiar compartments. The basis for the structural assignment is clustering of voxels based on patterns of enhancer expression. These initial clusters are agglomerated to make hierarchical predictions of structure. We applied the algorithm to central brain regions receiving input from the optic lobes. Based on the automated segmentation and manual validation, we can identify and provide promising driver lines for 11 previously identified and 14 novel types of visual projection neurons and their associated optic glomeruli. The same strategy can be used in other brain regions and likely other species, including vertebrates.
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Registered trials
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