ArticleCurrent biology : CB2016
Systems Analysis of the Dynamic Inflammatory Response to Tissue Damage Reveals Spatiotemporal Properties of the Wound Attractant Gradient.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed.
- Tissue flow acts as a guidance cue for immune cell polarization and directional migration.Nature cell biology · 2026Article
- Harmonic fields and the mechanical response of a cellular monolayer to ablation.Journal of mathematical biology · 2026Article
- Deciphering antigen-specific T cell navigation tactics and cancer immune evasion in co-cultures.Communications biology · 2025Article
- Drosophila complement-like Mcr acts as a wound-induced inflammatory chemoattractant.Current biology : CB · 2025Article
- Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair.eLife · 2024Article
- Deep learning reveals a damage signalling hierarchy that coordinates different cell behaviours driving wound re-epithelialisation.Development (Cambridge, England) · 2024Article
- Natural Affinity Driven Modification by Silicene to Construct a "Thermal Switch" for Tumorous Bone Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024Review
- Rapid Preparation of Living Drosophila Pupal Macrophages for Ex Vivo Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A PI3K-calcium-Nox axis primes leukocyte Nrf2 to boost immune resilience and limit collateral damage.The Journal of cell biology · 2023Article
- Tailored biomedical materials for wound healing.Burns & trauma · 2023Review
- What good is maths in studies of wound healing?iScience · 2022Review
- Article
- Insights on the NF-κB System Using Live Cell Imaging: Recent Developments and Future Perspectives.Frontiers in immunology · 2022Review
- CK1α protects WAVE from degradation to regulate cell shape and motility in the immune response.Journal of cell science · 2021Article
- PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo.Current biology : CB · 2021Article
- Learning the dynamics of cell-cell interactions in confined cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cell Migration Guided by Cell-Cell Contacts in Innate Immunity.Trends in cell biology · 2021Review
- Notch Signaling Regulates Muscle Stem Cell Homeostasis and Regeneration in a Teleost Fish.Frontiers in cell and developmental biology · 2021Article
- Igniting the spread of ferroptotic cell death.Nature cell biology · 2020Article
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6 authors.
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Abstract
In the acute inflammatory phase following tissue damage, cells of the innate immune system are rapidly recruited to sites of injury by pro-inflammatory mediators released at the wound site. Although advances in live imaging allow us to directly visualize this process in vivo, the precise identity and properties of the primary immune damage attractants remain unclear, as it is currently impossible to directly observe and accurately measure these signals in tissues. Here, we demonstrate that detailed information about the attractant signals can be extracted directly from the in vivo behavior of the responding immune cells. By applying inference-based computational approaches to analyze the in vivo dynamics of the Drosophila inflammatory response, we gain new detailed insight into the spatiotemporal properties of the attractant gradient. In particular, we show that the wound attractant is released by wound margin cells, rather than by the wounded tissue per se, and that it diffuses away from this source at rates far slower than those of previously implicated signals such as H2O2 and ATP, ruling out these fast mediators as the primary chemoattractant. We then predict, and experimentally test, how competing attractant signals might interact in space and time to regulate multi-step cell navigation in the complex environment of a healing wound, revealing a period of receptor desensitization after initial exposure to the damage attractant. Extending our analysis to model much larger wounds, we uncover a dynamic behavioral change in the responding immune cells in vivo that is prognostic of whether a wound will subsequently heal or not. VIDEO ABSTRACT.
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