ArticleThe Journal of physiology2016
Exogenous and endogenous angiotensin-II decrease renal cortical oxygen tension in conscious rats by limiting renal blood flow.
Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Renal R2* as a noninvasive predictor of hepatorenal syndrome-acute kidney disease in cirrhotic patients with ascites: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Hypoxia-Inducible Factors and Diabetic Kidney Disease-How Deep Can We Go?International journal of molecular sciences · 2022Review
- Renal blood flow and oxygenation.Pflugers Archiv : European journal of physiology · 2022Review
- The intrinsic piezoelectric properties of materials - a review with a focus on biological materials.RSC advances · 2021Review
- Role of Renal Sympathetic Nerve Activity in Volatile Anesthesia's Effect on Renal Excretory Function.Function (Oxford, England) · 2021Article
- Reversible (Patho)Physiologically Relevant Test Interventions: Rationale and Examples.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Quantitative Assessment of Renal Perfusion and Oxygenation by Invasive Probes: Basic Concepts.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Monitoring Renal Hemodynamics and Oxygenation by Invasive Probes: Experimental Protocol.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Protective potential of curcumin in L-NAME-induced hypertensive rat model: AT1R, mitochondrial DNA synergy.International journal of physiology, pathophysiology and pharmacology · 2020Article
- A Computer Model of Oxygen Dynamics in the Cortex of the Rat Kidney at the Cell-Tissue Level.International journal of molecular sciences · 2019Article
- Role of Renal Hypoxia in the Progression From Acute Kidney Injury to Chronic Kidney Disease.Seminars in nephrology · 2019Review
- Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?Frontiers in physiology · 2019Review
- Angiotensin II-induced hypertension in rats is only transiently accompanied by lower renal oxygenation.Scientific reports · 2018Article
- Nitric Oxide Synthase Inhibition Induces Renal Medullary Hypoxia in Conscious Rats.Journal of the American Heart Association · 2018Article
- Sympathoexcitation following intermittent hypoxia in rat is mediated by circulating angiotensin II acting at the carotid body and subfornical organ.The Journal of physiology · 2018Article
- Renal Hypoxia in CKD; Pathophysiology and Detecting Methods.Frontiers in physiology · 2017Review
- Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease.Frontiers in physiology · 2017Review
- Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control.Frontiers in physiology · 2017Article
- Circadian Rhythm in Kidney Tissue Oxygenation in the Rat.Frontiers in physiology · 2017Article
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Authors and funding
9 authors at 7 institutions in 5 countries.
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Abstract
key pointsOur understanding of the mechanisms underlying the role of hypoxia in the initiation and progression of renal disease remains rudimentary. We have developed a method that allows wireless measurement of renal tissue oxygen tension in unrestrained rats. This method provides stable and continuous measurements of cortical tissue oxygen tension (PO2) for more than 2 weeks and can reproducibly detect acute changes in cortical oxygenation. Exogenous angiotensin-II reduced renal cortical tissue PO2 more than equi-pressor doses of phenylephrine, probably because it reduced renal oxygen delivery more than did phenylephrine. Activation of the endogenous renin-angiotensin system in transgenic Cyp1a1Ren2 rats reduced cortical tissue PO2; in this model renal hypoxia precedes the development of structural pathology and can be reversed acutely by an angiotensin-II receptor type 1 antagonist. Angiotensin-II promotes renal hypoxia, which may in turn contribute to its pathological effects during development of chronic kidney disease. ABSTRACT: We hypothesised that both exogenous and endogenous angiotensin-II (AngII) can decrease the partial pressure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the progression of chronic kidney disease. Rats were instrumented with telemeters equipped with a carbon paste electrode for continuous measurement of renal cortical tissue PO2. The method reproducibly detected acute changes in cortical oxygenation induced by systemic hyperoxia and hypoxia. In conscious rats, renal cortical PO2 was dose-dependently reduced by intravenous AngII. Reductions in PO2 were significantly greater than those induced by equi-pressor doses of phenylephrine. In anaesthetised rats, renal oxygen consumption was not affected, and filtration fraction was increased only in the AngII infused animals. Oxygen delivery decreased by 50% after infusion of AngII and renal blood flow (RBF) fell by 3.3 ml min
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