Evidence map›Paper›PMID 27426090›Full record

ArticleInternational journal of stem cells2016

Treatment of Cerebral Palsy with Stem Cells: A Report of 17 Cases.

Nassim H Abi Chahine, Tarek W Wehbe, Ramzi A Hilal, Victoria V Zoghbi, Alia E Melki, Emil B Bou Habib

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stem cells, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  11. Is there a place for cellular therapy in depression?World journal of psychiatry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nassim H Abi ChahineNeurosurgery, The Lebanese-Canadian Hospital, Beirut, Lebanon.
Tarek W WehbeHead of the Department of Hematology, Notre Dame Du Liban University Hospital and The Lebanese-Canadian Hospital, Beirut, Lebanon.
Ramzi A HilalNeurology, Head of the Department, The Lebanese-Canadian Hospital, Beirut,Lebanon.
Victoria V ZoghbiAnesthesiology and Reanimation, Salam Hospital, Tripoli, Lebanon.
Alia E MelkiDoctorate of Acupuncture and TCM, The Five Elements Wellness Center, Koura, Lebanon.
Emil B Bou HabibNeurosurgery, Head of Department, The Lebanese-Canadian Hospital, Beirut, Lebanon.
Lebanese Canadian University · LBAl-Salam Hospital · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral Palsy (CP) is a disabling condition that affects a child's life and his/her family irreversibly. It is usually a non-progressive condition but improvement over time is rarely seen. The condition can be due to prenatal hypoxia, metabolic, genetic, infectious, traumatic or other causes. It is therefore a heterogeneous group that results in functional motor disability associated with different degrees of cognitive abnormalities. There are no treatments that can cure or even improve CP and the best available approach aims at functional, social and nutritional supportive care and counseling. In this paper, we report 17 sequential patients with CP treated with intrathecal administration of Bone Marrow Mononuclear Cells (BMMC). All patients had an uneventful post-injection course with 73% of the evaluable patients treated having a good response using the Gross Motor Function Classification System (GMFCS). The average improvement was 1.3 levels on the GMFCS with cognitive improvements as well.

Indexed as

Bone Marrow Mononuclear CellsCerebral palsyIntrathecal injectionStem cells

Identifiers

PMID27426090
PMCPMC4961108
OpenAlexW2395048283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.