ArticleACS nano2016
(19)F Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures Are Strongly Affected by Their Shape.
Article in ACS nano, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Lipopeptides as tools in catalysis, supramolecular, materials and medicinal chemistry.Nature reviews. Chemistry · 2023Review
- Fluorinated Protein and Peptide Materials for Biomedical Applications.Pharmaceuticals (Basel, Switzerland) · 2022Review
- The Design of Abnormal Microenvironment Responsive MRI Nanoprobe and Its Application.International journal of molecular sciences · 2021Review
- Fluorinated peptide biomaterials.Peptide science (Hoboken, N.J.) · 2021Article
- Using High Molecular Precision to Study Enzymatically Induced Disassembly of Polymeric Nanocarriers: Direct Enzymatic Activation or Equilibrium-Based Degradation?Macromolecules · 2021Review
- Functional Imaging Using Fluorine (Methods in molecular biology (Clifton, N.J.) · 2021Article
- The ratio of hydrogelator to precursor controls the enzymatic hydrogelation of a branched peptide.Soft matter · 2020Article
- Biomaterials based on noncovalent interactions of small molecules.EXCLI journal · 2020Review
- Impact of charge switching stimuli on supramolecular perylene monoimide assemblies.Chemical science · 2019Article
- Protein-Engineered Nanoscale Micelles for DynamicACS nano · 2019Article
- Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging.ACS nano · 2018Article
- Peptide supramolecular materials for therapeutics.Chemical Society reviews · 2018Article
- Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected byACS applied materials & interfaces · 2017Article
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Authors and funding
6 authors.
Funding
Abstract
Magnetic resonance imaging (MRI) is a noninvasive imaging modality that provides excellent spatial and temporal resolution. The most commonly used MR probes face significant challenges originating from the endogenous (1)H background signal of water. In contrast, fluorine MRI ((19)F MRI) allows quantitative probe imaging with zero background signal. Probes with high fluorine content are required for high sensitivity, suggesting nanoscale supramolecular assemblies containing (19)F probes offer a potentially useful strategy for optimum imaging as a result of improved payload. We report here on supramolecular nanostructures formed by fluorinated peptide amphiphiles containing either glutamic acid or lysine residues in their sequence. We identified molecules that form aggregates in water which transition from cylindrical to ribbon-like shape as pH increased from 4.5 to 8.0. Interestingly, we found that ribbon-like nanostructures had reduced magnetic resonance signal, whereas their cylindrical counterparts exhibited strong signals. We attribute this drastic difference to the greater mobility of fluorinated tails in the hydrophobic compartment of cylindrical nanostructures compared to lower mobility in ribbon-like assemblies. This discovery identifies a strategy to design supramolecular, self-assembling contrast agents for (19)F MRI that can spatially map physiologically relevant changes in pH using changes in morphology.
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