ArticleCell reports2016
Formation of a "Pre-mouth Array" from the Extreme Anterior Domain Is Directed by Neural Crest and Wnt/PCP Signaling.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Small molecules direct the generation of ameloblast-like cells from human embryonic stem cells.Stem cell research & therapy · 2025Article
- Small Molecules Promote the Rapid Generation of Dental Epithelial Cells from Human-Induced Pluripotent Stem Cells.International journal of molecular sciences · 2024Article
- Fgf signalling is required for gill slit formation in the skate, Leucoraja erinacea.Developmental biology · 2024Article
- Jak2 and Jaw Muscles Are Required for Buccopharyngeal Membrane Perforation during Mouth Development.Journal of developmental biology · 2023Article
- Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development inFrontiers in physiology · 2019Article
- The Many Faces ofFrontiers in physiology · 2019Article
- Article
- Identification ofGenetics · 2018Article
- Models of convergent extension during morphogenesis.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Mouth development.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Role of JNK during buccopharyngeal membrane perforation, the last step of embryonic mouth formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The mouth arises from the extreme anterior domain (EAD), a region where the ectoderm and endoderm are directly juxtaposed. Here, we identify a "pre-mouth array" in Xenopus that forms soon after the cranial neural crest has migrated to lie on either side of the EAD. Initially, EAD ectoderm comprises a wide and short epithelial mass that becomes narrow and tall with cells and nuclei changing shape, a characteristic of convergent extension. The resulting two rows of cells-the pre-mouth array-later split down the midline to surround the mouth opening. Neural crest is essential for convergent extension and likely signals to the EAD through the Wnt/planar cell polarity (PCP) pathway. Fzl7 receptor is locally required in EAD ectoderm, while Wnt11 ligand is required more globally. Indeed, heterologous cells expressing Wnt11 can elicit EAD convergent extension. The study reveals a precise cellular mechanism that positions and contributes to the future mouth.
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Registered trials
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