ArticleScientific reports2016
Identification and functional analysis of endogenous nitric oxide in a filamentous fungus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Metabolic modulation of TCA cycle bySynthetic and systems biotechnology · 2026Article
- GSNOR is essential for nitric oxide homeostasis and involved in aflatoxin biosynthesis and pathogenicity inApplied and environmental microbiology · 2026Article
- The Role of Nitric Oxide in the Growth and Development ofMicroorganisms · 2025Article
- Role of Flavohemoglobins in the Development and Aflatoxin Biosynthesis ofJournal of fungi (Basel, Switzerland) · 2024Article
- Nitric Oxide in Fungi: Production and Function.Journal of fungi (Basel, Switzerland) · 2024Review
- RNA-Seq-Based Transcriptome Analysis of Nitric Oxide Scavenging Response inJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- Eco-Friendly Solution Based onInternational journal of molecular sciences · 2022Article
- Intracellular production of reactive oxygen species and a DAF-FM-related compound in Aspergillus fumigatus in response to antifungal agent exposure.Scientific reports · 2022Article
- Nitric Oxide Metabolism Affects Germination inJournal of fungi (Basel, Switzerland) · 2022Article
- MaNCP1, a C2H2 Zinc Finger Protein, Governs the Conidiation Pattern Shift through Regulating the Reductive Pathway for Nitric Oxide Synthesis in the Filamentous Fungus MetarhiziumMicrobiology spectrum · 2022Article
- A global search for novel transcription factors impacting the Neurospora crassa circadian clock.G3 (Bethesda, Md.) · 2021Article
- Cadmium Stress Reprograms ROS/RNS Homeostasis inInternational journal of molecular sciences · 2020Article
- Regulators of nitric oxide signaling triggered by host perception in a plant pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Effect of Nitrosative Stress on theFrontiers in microbiology · 2020Article
- Nitric oxide increases biofilm formation inBiotechnology for biofuels · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In spite of its prevalence in animals and plants, endogenous nitric oxide (NO) has been rarely reported in fungi. We present here our observations on production of intracellular NO and its possible roles during development of Neurospora crassa, a model filamentous fungus. Intracellular NO was detected in hypha 8-16 hours after incubation in Vogel's minimal liquid media and conidiophores during conidiation using a fluorescent indicator (DAF-FM diacetate). Treatment with cPTIO, an NO scavenger, significantly reduced fluorescence levels and hindered hyphal growth in liquid media and conidiation, whereas exogenous NO enhanced hyphal extension on VM agar media and conidia formation. NO scavenging also dramatically diminished transcription of con-10 and con-13, genes preferentially expressed during conidiation. Our results suggest that intracellular NO is generated in young hypha growing in submerged culture and during conidia development and regulate mycelial development and conidia formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.