ArticleBehavioural brain research2016
Effects of sex and housing on social, spatial, and motor behavior in adult rats exposed to moderate levels of alcohol during prenatal development.
Article in Behavioural brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Intranasal Administration of KCNN2 Blocking Peptide Improves Deficits in Cognitive Flexibility in Mouse Model of Fetal Alcohol Spectrum Disorders.The international journal of neuropsychopharmacology · 2025Article
- The effects of moderate prenatal alcohol exposure on performance in object and spatial discrimination tasks by adult male rats.Behavioural brain research · 2025Article
- Organization of spontaneous spatial behaviors under dark conditions is unaffected in adult male and female long-Evans rats after moderate prenatal alcohol exposure.Behavioral neuroscience · 2025Article
- The Neurobiology of Learning and Memory in Rodent Models of Fetal Alcohol Spectrum Disorders.Advances in experimental medicine and biology · 2025Review
- The histamine HAlcohol (Fayetteville, N.Y.) · 2024Article
- Moderate prenatal alcohol exposure produces sex-specific social impairments and attenuates prelimbic excitability and amygdala-cortex modulation of adult social behaviour.Addiction biology · 2023Article
- Unraveling the complex relationship between prenatal alcohol exposure, hippocampal LTP, and learning and memory.Frontiers in molecular neuroscience · 2023Review
- Detection of prenatal alcohol exposure using machine learning classification of resting-state functional network connectivity data.Alcohol (Fayetteville, N.Y.) · 2021Article
- Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Article
- Altered Hippocampal Place Cell Representation and Theta Rhythmicity following Moderate Prenatal Alcohol Exposure.Current biology : CB · 2020Article
- The effects of developmental alcohol exposure on the neurobiology of spatial processing.Neuroscience and biobehavioral reviews · 2019Review
- Effects of prenatal alcohol exposure on social competence: Asymmetry in play partner preference among heterogeneous triads of male and female rats.Developmental psychobiology · 2019Article
- Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task.Behavioural brain research · 2019Article
- Prenatal alcohol exposure and sleep-wake behaviors: exploratory and naturalistic observations in the clinical setting and in an animal model.Sleep medicine · 2019Article
- Long-term Reductions in the Population of GABAergic Interneurons in the Mouse Hippocampus following Developmental Ethanol Exposure.Neuroscience · 2018Article
- Calcium chloride mimics the effects of acamprosate on cognitive deficits in chronic alcohol-exposed mice.Psychopharmacology · 2018Article
- Social Order: Using The Sequential Structure of Social Interaction to Discriminate Abnormal Social Behavior in the Rat.Learning and motivation · 2018Article
- Choline and Working Memory Training Improve Cognitive Deficits Caused by Prenatal Exposure to Ethanol.Nutrients · 2017Article
- Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development.Behavioural brain research · 2017Article
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Authors and funding
10 authors at 1 institution in 1 country.
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Abstract
Persistent deficits in social behavior, motor behavior, and behavioral flexibility are among the major negative consequences associated with exposure to ethanol during prenatal development. Prior work from our laboratory has linked moderate prenatal alcohol exposure (PAE) in the rat to deficits in these behavioral domains, which depend upon the ventrolateral frontal cortex (Hamilton et al., 2014) [20]. Manipulations of the social environment cause modifications of dendritic morphology and experience-dependent immediate early gene expression in ventrolateral frontal cortex (Hamilton et al., 2010) [19], and may yield positive behavioral outcomes following PAE. In the present study we evaluated the effects of housing PAE rats with non-exposed control rats on adult behavior. Rats of both sexes were either paired with a partner from the same prenatal treatment condition (ethanol or saccharin) or from the opposite condition (mixed housing condition). At four months of age (∼3 months after the housing manipulation commenced), social behavior, tongue protrusion, and behavioral flexibility in the Morris water task were measured as in (Hamilton et al., 2014) [20]. The behavioral effects of moderate PAE were primarily limited to males and were not ameliorated by housing with a non-ethanol exposed partner. Unexpectedly, social behavior, motor behavior, and spatial flexibility were adversely affected in control rats housed with a PAE rat (i.e., in mixed housing), indicating that housing with a PAE rat has broad behavioral consequences beyond the social domain. These observations provide further evidence that moderate PAE negatively affects social behavior, and underscore the importance of considering potential negative effects of housing with PAE animals on the behavior of critical comparison groups.
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