Evidence map›Paper›PMID 27424183›Full record

ReviewOral oncology2016

Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection.

Nijiro Nohata, Martin C Abba, J Silvio Gutkind

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Prevalence and Risk Factors of Human Papillomavirus in Male Patients: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2018
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Dentists Behavioral Factors Influencing Early Detection of Oral Cancer: Direct Clinical Observational Study.Journal of cancer education : the official journal of the American Association for Cancer Education · 2022
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Nijiro NohataMoores Cancer Center, University of California, San Diego, La Jolla, CA, United States.
Martin C AbbaCINIBA, CONICET, School of Medical Sciences, National University of La Plata, La Plata, Argentina.
J Silvio GutkindMoores Cancer Center, University of California, San Diego, La Jolla, CA, United States; Department of Pharmacology, University of California, San Diego, La Jolla, CA, United States. Electronic address: sgutkind@ucsd.edu.
University of California, San Diego · USUniversidad Nacional de La Plata · AR

Funding

ORAL CARCINOGENESISZ01DE000558 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI GUTKIND, J · 1992 to 2008
$3.6M
Intramural NIH HHS Z01 DE000558
6 · The paper itself

Abstract

objectivesThe role of long non-coding RNA (lncRNA) expression in human head and neck squamous cell carcinoma (HNSCC) is still poorly understood. In this study, we aimed at establishing the onco-lncRNAome profiling of HNSCC and to identify lncRNAs correlating with prognosis and patient survival. MATERIALS AND

methodsThe Atlas of Noncoding RNAs in Cancer (TANRIC) database was employed to retrieve the lncRNA expression information generated from The Cancer Genome Atlas (TCGA) HNSCC RNA-sequencing data. RNA-sequencing data from HNSCC cell lines were also considered for this study. Bioinformatics approaches, such as differential gene expression analysis, survival analysis, principal component analysis, and Co-LncRNA enrichment analysis were performed.

resultsUsing TCGA HNSCC RNA-sequencing data from 426 HNSCC and 42 adjacent normal tissues, we found 728 lncRNA transcripts significantly and differentially expressed in HNSCC. Among the 728 lncRNAs, 55 lncRNAs were significantly associated with poor prognosis, such as overall survival and/or disease-free survival. Next, we found 140 lncRNA transcripts significantly and differentially expressed between Human Papilloma Virus (HPV) positive tumors and HPV negative tumors. Thirty lncRNA transcripts were differentially expressed between TP53 mutated and TP53 wild type tumors. Co-LncRNA analysis suggested that protein-coding genes that are co-expressed with these deregulated lncRNAs might be involved in cancer associated molecular events. With consideration of differential expression of lncRNAs in a HNSCC cell lines panel (n=22), we found several lncRNAs that may represent potential targets for diagnosis, therapy and prevention of HNSCC.

conclusionLncRNAs profiling could provide novel insights into the potential mechanisms of HNSCC oncogenesis.

Indexed as

Carcinoma, Squamous CellGene Expression ProfilingGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansPapillomavirus InfectionsRNA, Long NoncodingRNA, Long NoncodingHead and neck squamous cell carcinoma (HNSCC)Human papilloma virus (HPV)Long non-coding RNARNA-sequencingTCGATP53

Identifiers

PMID27424183
PMCPMC5729891
OpenAlexW2469960007

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.