ArticleJournal of psychiatric research2016
Duration of attenuated positive and negative symptoms in individuals at clinical high risk: Associations with risk of conversion to psychosis and functional outcome.
Article in Journal of psychiatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Incidence and Persistence of Psychotic Experiences in the General Population: Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2023Pooled it
- Negative symptoms in children and adolescents with early-onset psychosis and at clinical high-risk for psychosis: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science · 2023Pooled it
- EPA guidance on assessment of negative symptoms in schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2021Pooled it
- Negative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-analysis.Harvard review of psychiatryPooled it
- Baseline psychopathology and relationship to longitudinal functional outcome in attenuated and early first episode psychosis.Schizophrenia research · 2019Trial
- Reinforcement learning deficits in at-risk mental state for psychosis: the role of primary negative symptoms.European archives of psychiatry and clinical neuroscience · 2026Article
- Elevated defeatist performance beliefs predict state increases in negative symptoms in daily life in clinical high-risk for psychosis youth: implications for mobile health treatments.European archives of psychiatry and clinical neuroscience · 2026Article
- Subclinical and attenuated negative symptoms in the prediction of psychosis in children and adolescents: sample composition matters.European child & adolescent psychiatry · 2026Article
- Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2026Article
- Persistent negative symptoms in the EULAST cohort: impact on functional outcome.Schizophrenia (Heidelberg, Germany) · 2026Article
- The Negative Symptom Inventory-Psychosis Risk (NSI-PR): Psychometric Validation of the Final 11-Item Version.Schizophrenia bulletin · 2025Article
- Digital phenotyping evidence for the reduced positivity offset as a mechanism underlying anhedonia among individuals at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- IQ and socio-occupational functioning in relation to obsessive-compulsive symptoms severity in a clinical sample of adolescents.Scientific reports · 2025Article
- Persons at risk for psychosis overestimate social functioning compared to persons with major depressive disorder and community controls.Journal of psychiatric research · 2025Article
- Navigating the Maze: Caregiver Perspectives on Pathways to Mental Health Care for U.S. Youth at Clinical High Risk for Psychosis.Early intervention in psychiatry · 2025Article
- Cognitive Inflexibility Predicts Negative Symptoms Severity in Patients with First-Episode Psychosis: A 1-Year Follow-Up Study.Brain sciences · 2024Article
- Cognitive predictors of transition and remission of psychosis risk syndrome in a child and adolescent sample: longitudinal findings from the CAPRIS study.European child & adolescent psychiatry · 2024Article
- Correlations between Negative Symptoms and Cognitive Deficits in Individuals at First Psychotic Episode or at High Risk of Psychosis: A Systematic Review.Journal of clinical medicine · 2023Review
- Exploring the complex relationships between coping strategies, locus of control and self-esteem with psychopathology: structural equation modeling with a special focus on clinical high-risk of psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Development and Validation of the Negative Symptom Inventory-Psychosis Risk.Schizophrenia bulletin · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Research in individuals at clinical high-risk (CHR) for psychosis has focused on subjects with no more than 12 months of present or worsened attenuated positive symptoms. However, the impact of long duration attenuated positive and/or negative prodromal symptoms on outcomes is unclear. Seventy-six CHR subjects with attenuated positive symptoms and at least moderate severity level negative symptoms rated on the Scale of Prodromal Symptoms (SOPS) were prospectively followed for a mean of 3.0 ± 1.6 years. Social and Role functioning was assessed with the Global Functioning: Social and Role scales. Correlations between attenuated positive and negative symptom duration and severity and conversion to psychosis and functional outcomes were analyzed. The average onset of SOPS rated negative symptoms (M = 53.24 months, SD = 48.90, median = 37.27) was approximately twelve months prior to the emergence of attenuated positive symptom (M = 40.15 months, SD = 40.33, median = 24.77, P < 0.05). More severe positive symptoms (P = 0.004), but not longer duration of positive (P = 0.412) or negative (P = 0.754) symptoms, predicted conversion to psychosis. Neither positive symptom duration (P = 0.181) nor severity (P = 0.469) predicted role or social functioning at study endpoint. Conversely, longer negative symptom duration predicted poor social functioning (P = 0.004). Overall, our findings suggest that the severity of attenuated positive symptoms at baseline may be more important than symptom duration for determining individuals at increased risk of developing psychosis. In contrast, long-standing negative symptoms may be associated with persistent social difficulties and therefore have an important position in the treatment of disability.
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Registered trials
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