Evidence map›Paper›PMID 27423896›Full record

ArticleBioinformatics (Oxford, England)2016

LEVER: software tools for segmentation, tracking and lineaging of proliferating cells.

Mark Winter, Walter Mankowski, Eric Wait, Sally Temple, Andrew R Cohen

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. The Cluster Structure Function.IEEE transactions on pattern analysis and machine intelligence · 2023
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.Frontiers in bioengineering and biotechnology · 2021
    Article
  12. Probing pluripotency gene regulatory networks with quantitative live cell imaging.Computational and structural biotechnology journal · 2020
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark WinterDepartment of Electrical and Computer Engineering, Drexel University, Philadelphia, PA 19104, USA.
Walter MankowskiDepartment of Electrical and Computer Engineering, Drexel University, Philadelphia, PA 19104, USA.
Eric WaitDepartment of Electrical and Computer Engineering, Drexel University, Philadelphia, PA 19104, USA.
Sally TempleNeural Stem Cell Institute, Rensselaer, NY 12144, USA.
Andrew R CohenDepartment of Electrical and Computer Engineering, Drexel University, Philadelphia, PA 19104, USA.

Funding

Quantifying Changes in Neural Stem Cell Lineages in the Aging NicheR01AG041861 · NIA · REGENERATIVE RESEARCH FOUNDATION · PI COHEN, ANDREW ROBERT, TEMPLE, SALLY · 2012 to 2016
$2.1M
Analyzing Neural Stem Cell Clonal DevelopmentR01NS076709 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COHEN, ANDREW ROBERT · 2011 to 2015
$1.7M
NIA NIH HHS R01 AG041861NINDS NIH HHS R01 NS076709
6 · The paper itself

Abstract

The analysis of time-lapse images showing cells dividing to produce clones of related cells is an important application in biological microscopy. Imaging at the temporal resolution required to establish accurate tracking for vertebrate stem or cancer cells often requires the use of transmitted light or phase-contrast microscopy. Processing these images requires automated segmentation, tracking and lineaging algorithms. There is also a need for any errors in the automated processing to be easily identified and quickly corrected. We have developed LEVER, an open source software tool that combines the automated image analysis for phase-contrast microscopy movies with an easy-to-use interface for validating the results and correcting any errors. AVAILABILITY AND IMPLEMENTATION: LEVER is available free and open source, licensed under the GNU GPLv3. Details on obtaining and using LEVER are available at http://n2t.net/ark:/87918/d9rp4t CONTACT: acohen@coe.drexel.edu.

Indexed as

Cell LineageCell ProliferationSoftwareAlgorithmsAnimalsHumansImage Processing, Computer-AssistedMicroscopyMicroscopy, Phase-Contrast

Identifiers

PMID27423896
PMCPMC5181556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.