Evidence map›Paper›PMID 27423781›Full record

ArticleLung2016

Decreased TGF-β1 and VEGF Release in Cystic Fibrosis Platelets: Further Evidence for Platelet Defects in Cystic Fibrosis.

James P Maloney, Jayashree Narasimhan, Julie Biller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Microvascular significance of TGF-β axis activation in COVID-19.Frontiers in cardiovascular medicine · 2022
    Review
  3. Article
  4. Review
  5. NM23 proteins: innocent bystanders or local energy boosters for CFTR?Laboratory investigation; a journal of technical methods and pathology · 2018
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

James P MaloneyDivisions of Pulmonary and Critical Care Medicine, University of Colorado, Denver, 12700 East 19th Avenue, C-272, Aurora, Denver, CO, 80045, USA. james.maloney@ucdenver.edu.
Jayashree NarasimhanApollo Hospitals, Chennai, India.
Julie BillerThe Medical College of Wisconsin, Milwaukee, WI, USA.
Apollo Hospitals · INMedical College of Wisconsin · USUniversity of Colorado Denver · US

Funding

Structure and Function of TSP1 in Acute Lung InjuryR01HL071618 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MALONEY, JAMES P · 2004 to 2007
$1.5M
NHLBI NIH HHS R01 HL071618
6 · The paper itself

Abstract

purposeCystic fibrosis (CF) patients suffer from chronic lung inflammation. This inflammation may activate platelets. There are limited data on the role of platelet-secreted cytokines in CF. Platelet cytokines with inflammatory effects include vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1). As levels of these cytokines are tenfold greater in serum than plasma due to platelet release, serum levels may be one index of platelet content, but a more specific index is release during the aggregation of isolated platelets. We postulated that altered release of these platelet cytokines occurs in CF.

methodsWe obtained sera and plasma from CF outpatients (n = 21) and from healthy controls (n = 20), measured VEGF and TGF-β1, assessed for correlations with platelet number, analyzed cytokine release during platelet aggregation to collagen, and analyzed differences in maximal platelet aggregation.

resultsPlatelet number and maximal aggregation levels were higher in CF. Plasma and serum levels of TGF-β1 and VEGF were higher in CF, but these levels were similar after adjusting for platelet number (serum cytokines correlated with platelet count). The release of VEGF and TGF-β1 during aggregation was decreased in CF platelets (by 52 and 29 %, respectively).

conclusionPlatelet release is not a source of the elevated blood proinflammatory cytokines TGF-β1 and VEGF in CF, as platelets from CF patients actually release less of these cytokines. These data provide further evidence for platelet defects in CF.

Indexed as

AdultBlood PlateletsCase-Control StudiesCystic FibrosisFemaleHumansMalePlasmaPlatelet AggregationPlatelet CountSerumTransforming Growth Factor beta1Vascular Endothelial Growth Factor ATransforming Growth Factor beta1Vascular Endothelial Growth Factor AVEGFA protein, humanCystic fibrosisPlatelet aggregationPlateletsTransforming growth factor-βVascular endothelial growth factor

Identifiers

PMID27423781
PMCPMC5033711
OpenAlexW2460549106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.