Evidence map›Paper›PMID 27423676›Full record

Observational studyEuropean journal of radiology2016

Incidence of actionable findings on contrast enhanced magnetic resonance angiography ordered for pulmonary embolism evaluation.

Mark L Schiebler, Jitesh Ahuja, Michael D Repplinger, Christopher J François, Karl K Vigen, Thomas M Grist, Azita G Hamedani, Scott B Reeder, Scott K Nagle

Open access · greenAbstract readComparative StudyObservational Study
In one paragraph

Observational study in European journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mark L SchieblerDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. Electronic address: mschiebler@uwhealth.org.
Jitesh AhujaDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Radiology, University of Washington School of Medicine, Seattle, WA, United States.
Michael D RepplingerDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Christopher J FrançoisDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Karl K VigenDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Thomas M GristDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Azita G HamedaniDepartment of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Scott B ReederDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Emergency Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Biomedical Engineering, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Scott K NagleDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
University of Wisconsin–Madison · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427NIDDK NIH HHS K24 DK102595
6 · The paper itself

Abstract

purposeTo determine the incidence of actionable findings on contrast-enhanced magnetic resonance angiography (MRA) scans performed for the primary diagnosis of pulmonary embolism (PE). MATERIALS AND

methodsThis was a HIPAA-compliant and IRB-approved single center, retrospective study of consecutive series of patients evaluated with contrast-enhanced MRA for PE. The final radiology report of each MRA was reviewed. All technically adequate negative exams were included in the analysis. The findings were divided into three types: those requiring further action (actionable-Type 1) those not requiring follow-up (non-actionable-Type 2) and normal exams. We compared our results with the literature regarding the use of computed tomographic angiography (CTA) in this scenario using Fisher's exact test.

results580 MRA scans for PE were performed. There were 561/580 (97%) technically adequate exams. Of these, 514/580 (89%) were negative and 47/580 (8%) were positive for PE. In the PE negative group of 514 exams, Type 1 findings were identified in 85/514 (17%), 188/514 (36%) cases were Type 2 and 241/514 (47.0%) were Type 3. There was no significant difference between the incidence of Type 1 and the combination of Type 2 and Type 3 findings on MRA and the reported incidence of actionable findings derived from CTA negative exams for PE (p<0.5).

conclusionMRA as a first-line test for PE can identify actionable findings in those patients without PE, with an incidence similar to that reported in the literature for CTA.

Indexed as

Administration, IntravenousAdolescentAdultAgedAged, 80 and overAortic AneurysmAortic DiseasesChildContrast MediaDiagnosis, DifferentialFemaleHumansImage EnhancementIncidenceIncidental FindingsMagnetic Resonance AngiographyContrast Mediagadobenic acidMeglumineOrganometallic CompoundsAncillary findingsComputed tomography angiographyMagnetic resonance angiographyNon-thrombotic findingsPulmonary embolism

Identifiers

PMID27423676
PMCPMC7304888
OpenAlexW2408340969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.