Evidence map›Paper›PMID 27423658›Full record

ArticleNeuroradiology2016

Dilated perivascular spaces and fatigue: is there a link? Magnetic resonance retrospective 3Tesla study.

Renata Conforti, Mario Cirillo, Angela Sardaro, Giuseppina Caiazzo, Alberto Negro, Antonella Paccone, Rosaria Sacco, Maddalena Sparaco, Antonio Gallo, Luigi Lavorgna and 2 more

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In one paragraph

Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Renata ConfortiNeuroradiology Service, Department of Radiology, Second University of Naples, C/o CTO Viale dei Colli Aminei 21, Naples, Italy.
Mario CirilloNeuroradiology Service, Department of Radiology, Second University of Naples, C/o CTO Viale dei Colli Aminei 21, Naples, Italy.
Angela SardaroNeuroradiology Service, Department of Radiology, Second University of Naples, C/o CTO Viale dei Colli Aminei 21, Naples, Italy. sardaroangela@libero.it.
Giuseppina CaiazzoMRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
Alberto NegroNeuroradiology Service, Department of Radiology, Second University of Naples, C/o CTO Viale dei Colli Aminei 21, Naples, Italy.
Antonella PacconeMRI Research Center SUN-FISM, Second University of Naples, Naples, Italy.
Rosaria SaccoDepartment of Neurology, Second University of Naples, Naples, Italy.
Maddalena SparacoDepartment of Neurology, Second University of Naples, Naples, Italy.
Antonio GalloDepartment of Neurology, Second University of Naples, Naples, Italy.
Luigi LavorgnaDepartment of Neurology, Second University of Naples, Naples, Italy.
Gioacchino TedeschiDepartment of Neurology, Second University of Naples, Naples, Italy.
Sossio CirilloNeuroradiology Service, Department of Radiology, Second University of Naples, C/o CTO Viale dei Colli Aminei 21, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFatigue (F) is a common, inexplicable, and disabling symptom in multiple sclerosis (MS) patients. The purpose of this study was to evaluate a possible correlation between fatigue and morpho-volumetric features and site of dilated perivascular spaces (dPS), visible on 3T magnetic resonance (MR) in fatigued multiple sclerosis patients (FMS).

methodsWe studied 82 relapsing remitting (RR) FMS patients and 43 HC, matched for age, sex, and education. F was assessed by the Fatigue Severity Scale (FSS). To evaluate a possible correlation between degree of F and characteristics of dPS, patients were divided in two groups: more (mFMS) (FSS ≥ 5; n = 30) and less fatigued (lFMS) (FSS ≥ 4; n = 52), compared to a matched healthy control (HC) subject group. The MR study was performed with 3T scanner by SpinEcho T1, Fast-SpinEcho DP-T2, FLAIR, and 3D FSPGR T1 sequences. dPS volumes were measured with Medical Image Processing Analysis and Visualization (MIPAV); Global Cerebral Atrophy (GCA), expressed as Brain Parenchymal Fraction (BPF), was assessed by FSL SIENAX.

resultsThe t test showed significantly increased dPS number (p = 0.021) in FMS patients (mFMS p = 0.0024 and lFMS p = 0.033) compared to HC. Pearson correlation revealed a significant correlation between dPS number and FSS (r = 0.208 p = 0.051). Furthermore, the chi-squared test confirms the intragroup (HC, mFMS, lFMS) differences about dPS location (p = 0.01) and size (p = 0.0001).

conclusionOur study confirms that PS in MS patients presents with different volumetric and site characteristics as compared to HC; moreover, F severity significantly correlates with dPS number, site, and size.

Indexed as

AdultBrain DiseasesCausalityComorbidityDilatation, PathologicDouble-Blind MethodFatigueFemaleHumansItalyMagnetic Resonance ImagingMaleMultiple SclerosisPia MaterPrevalenceReproducibility of ResultsDilated perivascular spaces (dPS)Dilated Virchow-Robin spaces (dVRS)Fatigue (F)Multiple sclerosis (MS)

Identifiers

PMID27423658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.