Evidence map›Paper›PMID 27423389›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2017

Force regulated conformational change of integrin α

Yunfeng Chen, Hyunjung Lee, Haibin Tong, Martin Schwartz, Cheng Zhu

Abstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 94 citations in OpenAlex.

  1. The role of [European journal of nuclear medicine and molecular imaging · 2023
    Trial
  2. All-atom simulations reveal distinct pathways for αCellular and molecular life sciences : CMLS · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Conformational response of αStructure (London, England : 1993) · 2025
    Article
  7. Interaction of integrin αFrontiers in cell and developmental biology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Integrin αBiophysical journal · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Yunfeng ChenWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Hyunjung LeeCoulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Haibin TongYale Cardiovascular Research Center, Departments of Internal Medicine (Section of Cardiovascular Medicine), Cell Biology and Biomedical Engineering, Yale University, New Haven, CT 06511, USA; Current address: Life Science Research Center, Beihua University, Jilin 132013, China.
Martin SchwartzYale Cardiovascular Research Center, Departments of Internal Medicine (Section of Cardiovascular Medicine), Cell Biology and Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Cheng ZhuWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: cheng.zhu@bme.gatech.edu.
Georgia Institute of Technology · USBeihua University · CNYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Visualizing Single Integrin Conformational Changes on Living CellsR01AI044902 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2000 to 2016
$5.8M
Single-platelet analysis of mechano-reception by GPIb alphaR01HL132019 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI ZHU, CHENG · 2016 to 2024
$3.8M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL132019NIAID NIH HHS R01 AI044902
6 · The paper itself

Abstract

Integrins mediate cell adhesion to extracellular matrix and transduce signals bidirectionally across the membrane. Integrin α

Indexed as

AnimalsBiomechanical PhenomenaBiotinylationCell AdhesionCell LineEndothelial CellsErythrocytesExtracellular MatrixFibronectinsGene ExpressionGlassHumansIntegrin alphaVbeta3KineticsLungMiceFibronectinsfibronectin type III like peptide, humanIntegrin alphaVbeta3Molecular ProbesBinding kineticsBiomechanicsForce regulationIntegrin conformational changeIntegrin α(V)β(3)

Identifiers

PMID27423389
PMCPMC5237428
OpenAlexW2471742475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.