Evidence map›Paper›PMID 27423324›Full record

ArticlePhysiology & behavior2017

Reduced marker of vascularization in the anterior hippocampus in a female monkey model of depression.

Anisha Kalidindi, Sean D Kelly, Kaela S Singleton, Dora Guzman, Liana Merrill, Stephanie L Willard, Carol A Shively, Gretchen N Neigh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiology & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anisha KalidindiDepartment of Biology, Emory College, Atlanta, GA, USA.
Sean D KellyDepartment of Physiology, Emory University, Atlanta, GA, USA.
Kaela S SingletonNeuroscience and Behavioral Biology, Agnes Scott College, Decatur, GA, USA.
Dora GuzmanDepartment of Psychiatry & Behavioral Science, Emory University, Atlanta, GA, USA.
Liana MerrillDepartment of Physiology, Emory University, Atlanta, GA, USA.
Stephanie L WillardDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Carol A ShivelyDepartment of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Gretchen N NeighDepartment of Physiology, Emory University, Atlanta, GA, USA; Department of Psychiatry & Behavioral Science, Emory University, Atlanta, GA, USA. Electronic address: gretchen.mccandless@vcuhealth.org.
Emory University · USWake Forest University · USAgnes Scott College · USEmory and Henry College · US

Funding

Dietary Mitigation of Psychosocial Stress Effects on CVD Risk R01HL087103 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHIVELY, CAROL A. · 2007 to 2017
$6.0M
BP-ENDURE-Atlanta: Engaging Undergraduates in Neuroscience ResearchR25NS080688 · NINDS · GEORGIA STATE UNIVERSITY · PI FRANTZ, KYLE J. · 2012 to 2016
$1.2M
BP-ENDURE-Atlanta: Engaging Undergraduates in Neuroscience ResearchR25GM097636 · NIGMS · GEORGIA STATE UNIVERSITY · PI FRANTZ, KYLE J. · 2010 to 2011
$517k
Cellular and Molecular Basis of Hippocampal Atrophy in Depressed Female MonkeysR21MH086731 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHIVELY, CAROL A. · 2009 to 2010
$407k
NHLBI NIH HHS R01 HL087103NIGMS NIH HHS R25 GM097636NIMH NIH HHS R21 MH086731NINDS NIH HHS R25 NS080688
6 · The paper itself

Abstract

Depression is a common and debilitating mood disorder that impacts women more often than men. The mechanisms that result in depressive behaviors are not fully understood; however, the hippocampus has been noted as a key structure in the pathophysiology of depression. In addition to neural implications of depression, the cardiovascular system is impacted. Although not as commonly considered, the cerebrovasculature is critical to brain function, impacted by environmental stimuli, and is capable of altering neural function and thereby behavior. In the current study, we assessed the relationship between depressive behavior and a marker of vascularization of the hippocampus in adult female cynomolgus macaques (Macaca fascicularis). Similar to previously noted impacts on neuropil and glia, the depressed phenotype predicts a reduction in a marker of vascular length in the anterior hippocampus. These data reinforce the growing recognition of the effects of depression on vasculature and support further consideration of vascular endpoints in studies aimed at the elucidation of the mechanisms underlying depression.

Indexed as

Disease Models, AnimalAnimalsDepressionFemaleGlucose Transporter Type 1HippocampusImmunohistochemistryMacaca fascicularisGlucose Transporter Type 1CerebrovasculatureDepressionFemaleHippocampusMacaca fascicularisUnbiased stereologyVascular

Identifiers

PMID27423324
PMCPMC5237427
OpenAlexW2468237505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.