Evidence map›Paper›PMID 27423055›Full record

Trial reportClinical transplantation2016

Effect of moderately intense perioperative glucose control on renal allograft function: a pilot randomized controlled trial in renal transplantation.

Justin Parekh, Garrett R Roll, Steven Wisel, Robert J Rushakoff, Ryutaro Hirose

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01643382 (Randomized Study of the Impact of Peri-operative Glucose Control on Short Term Renal Allograft Function After Transplantation), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01643382 nacompletednot on this map

Randomized Study of the Impact of Peri-operative Glucose Control on Short Term Renal Allograft Function After Transplantation

TypeinterventionalSponsorUniversity of California, San FranciscoRan2012 to 2014Enrolled60ConditionsDiabetes, End Stage Renal DiseaseArmsInsulin, Insulin, Asp(B28)-
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Perioperative glycaemic control for people with diabetes undergoing surgery.The Cochrane database of systematic reviews · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Justin ParekhDivision of Transplantation, Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA. justin.parekh@utsouthwestern.edu.
Garrett R RollDivision of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Steven WiselDivision of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
Robert J RushakoffDepartment of Endocrinology, University of California San Francisco, San Francisco, CA, USA.
Ryutaro HiroseDivision of Transplantation, Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USUniversity of San Francisco · USSouthwestern Medical Center · US

Funding

Filling a Void of Research (FAVOR) Training for Transplant SurgeonsT32AI125222 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PETER G STOCK, Minnie M Sarwal · 2016 to 2026
$3.4M
NIAID NIH HHS T32 AI125222
6 · The paper itself

Abstract

Recipient diabetes accounts for ~34% of end-stage renal disease in patients awaiting renal transplantation and has been linked to poor graft function. We conducted a single-center, open-label, randomized controlled trial to determine whether moderately intense glucose control during allograft reperfusion would reduce the incidence of poor graft function. Adult diabetics undergoing deceased donor renal transplant were randomized to moderately intense glucose control (n=30) or standard control (n=30). The primary outcome was poor graft function (dialysis within seven days of transplant or failure of serum creatinine to fall by 10% for three consecutive days). Recipients with moderately intense glucose control had less poor graft function in the intention-to-treat (43.3% vs 73.3%, P=.02) and per-protocol analysis (43.2% vs 81%, P<.01). Recipients with moderately intense control also had higher glomerular filtration rate (GFR) at 30 days after transplant in the per-protocol and intention-to-treat analyses. There were no episodes of severe hypoglycemia in either group and no differences in mortality, seizures, stroke, graft loss, or biopsy-proven rejection. Moderately intense glucose control at the time of allograft reperfusion reduces the incidence of poor graft function in diabetic renal transplant recipients and improves glomerular filtration rate at 30 days.

Indexed as

Kidney TransplantationAdultAgedBiomarkersBlood GlucoseDelayed Graft FunctionDiabetic NephropathiesFemaleFollow-Up StudiesGlomerular Filtration RateHumansHyperglycemiaHypoglycemiaIncidenceIntention to Treat AnalysisKidney Failure, ChronicBiomarkersBlood Glucosedelayed graft functiondiabeteshyperglycemiakidney transplantationpoor graft function

Identifiers

PMID27423055
PMCPMC8354204
OpenAlexW2472079485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.