ArticleThe American journal of pathology2016
Activation of Dopamine D1 Receptors in Dermal Fibroblasts Restores Vascular Endothelial Growth Factor-A Production by These Cells and Subsequent Angiogenesis in Diabetic Cutaneous Wound Tissues.
Article in The American journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response.Current neuropharmacology · 2020Pooled it
- Modular living assembly of bone organoids with in situ guided vascularization.Bioactive materials · 2026Article
- Insights into small-molecule neurotransmitter levels and distribution during tissue regeneration in an ear pinna model in mice.Scientific reports · 2026Article
- The effect of peripheral dopamine on fracture healing: an experimental study in a rat model.Journal of orthopaedic surgery and research · 2025Article
- Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors.Investigative ophthalmology & visual science · 2025Article
- A toxic gain-of-function variant in MAPK8IP3 provides insights into JIP3 cellular roles.JCI insight · 2025Article
- Impact of chronic social stress on molecular markers of skin regeneration during experimental excisional wounding.Frontiers in immunology · 2025Article
- Mapping intellectual structure and research hotspots in the field of fibroblast-associated DFUs: a bibliometric analysis.Frontiers in endocrinology · 2023Article
- Effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization in high myopia mice.International journal of ophthalmology · 2023Article
- Growth Factor Binding Peptides in Poly (Ethylene Glycol) Diacrylate (PEGDA)-Based Hydrogels for an Improved Healing Response of Human Dermal Fibroblasts.Gels (Basel, Switzerland) · 2022Article
- Effect of Antilogous Platelet-Rich Plasma on the Revascularization of Rabbit Prefabricated Flap.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- VEGF-A controls the expression of its regulator of angiogenic functions, dopamine D2 receptor, on endothelial cells.Journal of cell science · 2022Article
- Role of neurotransmitters in the regulation of cutaneous wound healing.Experimental brain research · 2022Review
- Dopamine Prevents Ultraviolet B-induced Development and Progression of Premalignant Cutaneous Lesions through its DCancer prevention research (Philadelphia, Pa.) · 2021Article
- Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF-A induced angiogenesis.Molecular carcinogenesis · 2021Article
- Chebulinic acid is a safe and effective antiangiogenic agent in collagen-induced arthritis in mice.Arthritis research & therapy · 2020Article
- Catecholamines in the regulation of angiogenesis in cutaneous wound healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Review
- A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing.Molecules (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In wound beds, fibroblasts are rich sources of vascular endothelial growth factor A, a cytokine necessary for promoting angiogenesis and thereby the healing of wound tissues. However, in diabetes mellitus, these cells are functionally impaired and produce reduced amounts of vascular endothelial growth factor A, resulting in deficient angiogenesis and delayed wound healing. We here for the first time demonstrate that stimulation of D1 dopamine receptors present in dermal fibroblasts restores vascular endothelial growth factor A production by these cells, resulting in adequate angiogenesis and subsequent healing of cutaneous wounds in both type 1 and type 2 diabetic mice. This action of D1 dopamine receptors was mediated through the protein kinase A pathway. As delayed wound healing or chronic wounds are one of the major health problems in diabetic patients, D1 dopamine receptor agonists, which are already in clinical use for the treatment of other disorders, may be of translational value in the treatment of chronic, nonhealing diabetic wounds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.