Evidence map›Paper›PMID 27422527›Full record

ArticleWorld journal of surgical oncology2016

Anorectal malignant melanoma: curative abdominoperineal resection: patient selection with 18F-FDG-PET/CT.

Claudius Falch, Sven Mueller, Andreas Kirschniak, Manuel Braun, Alfred Koenigsrainer, Bernhard Klumpp

Open access · goldAbstract read
In one paragraph

Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Malignant melanoma of the anal canal: a case report.Journal of surgical case reports · 2025
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  7. Review
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  13. 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Anorectal Malignant Melanoma: A Case Series.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
    Article
  14. Variable features ofWorld journal of nuclear medicine
    Article
  15. Diagnostic performance ofWorld journal of nuclear medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Claudius FalchDepartment of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany. claudius.falch@gmx.de.ORCID http://orcid.org/0000-0003-1595-7422
Sven MuellerDepartment of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.
Andreas KirschniakDepartment of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.
Manuel BraunDepartment of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.
Alfred KoenigsrainerDepartment of Surgery and Transplantation, University of Tuebingen, Hoppe-Seyler-Strasse 3, 72076, Tuebingen, Germany.
Bernhard KlumppDepartment of Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany.
University of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnorectal malignant melanomas (ARMM) are rare tumors, characterized by an early lymphatic spread and distant metastasis, resulting in an extremely poor overall survival. The objective of this study was to determine the pattern of regional lymph node metastasis (LNM) by computed tomography (CT) and 18F-FDG-PET/CT in patients undergoing abdominoperineal resection (APR) and its impact on oncologic outcome.

methodsA retrospective analysis of six consecutive patients who underwent APR due to primary ARMM was performed. Patients were staged by CT and PET/CT.

resultsFour out of six patients had preoperative LNM involvement (two patients inguinal and perirectal, one iliacal, one perirectal), with two of them presenting with distant metastases additionally. Inguinal/iliacal LNM in two patients as well as liver metastasis in one patient was seen in PET/CT and missed by CT. The three patients with initial inguinal/iliacal LNM died during the observation period (overall survival: 10 (6-18) months). The three patients without inguinal/iliacal LNM involvement are currently alive, one patient showing a slowly progressive disease since 5 years, and two patients are tumor-free since 8.5 and 1.5 years (the patients had initial perirectal LNM).

conclusionsIn ARMM, PET/CT is superior to CT in detection of LNM and distant metastasis. APR is possibly a curative approach if the PET/CT shows exclusively perirectal LNM despite locally advanced tumor growth.

Indexed as

Patient SelectionAgedAnal CanalAnus NeoplasmsColon, SigmoidFemaleFluorodeoxyglucose F18HumansLymphatic MetastasisLymph NodesMaleMelanomaMiddle AgedPositron Emission Tomography Computed TomographyRadiopharmaceuticalsRectal NeoplasmsFluorodeoxyglucose F18RadiopharmaceuticalsAbdominoperineal resectionAnal melanomaAnus neoplasmsColorectal surgeryComputed tomographyPETRectal melanoma

Identifiers

PMID27422527
PMCPMC4947294
OpenAlexW2466090993

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.