ReviewAdvances in nutrition (Bethesda, Md.)2016
Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015.
Review in Advances in nutrition (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Effects of Anthocyanins on Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- In vivo exposure to cranberry juice suppresses dental plaque regrowth and acid production in adults and children: a PGRM study.Scientific reports · 2026Trial
- Strawberries Improve Insulin Resistance and Related Cardiometabolic Markers in Adults with Prediabetes: A Randomized Controlled Crossover Trial.The Journal of nutrition · 2025Trial
- Dietary Blueberry and Soluble Fiber Supplementation Reduces Risk of Gestational Diabetes in Women with Obesity in a Randomized Controlled Trial.The Journal of nutrition · 2021Trial
- Cranberries improve postprandial glucose excursions in type 2 diabetes.Food & function · 2017Trial
- Impact of Low-Dose Cranberry Polyphenols on Gut Microbiota and Circulating Polyphenol Metabolites in Overweight and Obese Individuals (A Randomized Double-Blind Placebo-Controlled Clinical Pilot Study).Food science & nutrition · 2026Article
- Article
- Ex vivo oral biofilm model for rapid screening of antimicrobial agents including natural cranberry polyphenols.Scientific reports · 2025Article
- Dietary index for gut microbiota and its inverse association with female infertility: evidence from NHANES 2013-2018.Frontiers in nutrition · 2025Article
- In Silico Analysis of the Molecular Interaction between Anthocyanase, Peroxidase and Polyphenol Oxidase with Anthocyanins Found in Cranberries.International journal of molecular sciences · 2024Article
- Sports-Related Gastrointestinal Disorders: From the Microbiota to the Possible Role of Nutraceuticals, a Narrative Analysis.Microorganisms · 2024Review
- Quality Evaluation of Muffins Enriched With Blueberry and Cranberry Powders.International journal of food science · 2024Article
- Anthocyanin Effects on Vascular and Endothelial Health: Evidence from Clinical Trials and Role of Gut Microbiota Metabolites.Antioxidants (Basel, Switzerland) · 2023Review
- Phytochemical Composition of the Fruit of Large Cranberry (Plants (Basel, Switzerland) · 2023Article
- Cranberry: Chemical Composition, Antioxidant Activity and Impact on Human Health: Overview.Molecules (Basel, Switzerland) · 2022Review
- Dietary Strawberries Improve Biomarkers of Antioxidant Status and Endothelial Function in Adults with Cardiometabolic Risks in a Randomized Controlled Crossover Trial.Antioxidants (Basel, Switzerland) · 2021Article
- Gut Microbiome, Functional Food, Atherosclerosis, and Vascular Calcifications-Is There a Missing Link?Microorganisms · 2021Review
- Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model.Microbial cell (Graz, Austria) · 2021Article
- Lyophilized Maqui (Antioxidants (Basel, Switzerland) · 2021Article
- Cranberry (AIMS microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in cranberry research have expanded the evidence for the role of this Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors. The A-type structure of cranberry proanthocyanidins seems to be responsible for much of this fruit's efficacy as a natural antimicrobial. Cranberry proanthocyanidins interfere with colonization of the gut by extraintestinal pathogenic Escherichia coli in vitro and attenuate gut barrier dysfunction caused by dietary insults in vivo. Furthermore, new studies indicate synergy between these proanthocyanidins, other cranberry components such as isoprenoids and xyloglucans, and gut microbiota. Together, cranberry constituents and their bioactive catabolites have been found to contribute to mechanisms affecting bacterial adhesion, coaggregation, and biofilm formation that may underlie potential clinical benefits on gastrointestinal and urinary tract infections, as well as on systemic anti-inflammatory actions mediated via the gut microbiome. A limited but growing body of evidence from randomized clinical trials reveals favorable effects of cranberry consumption on measures of cardiometabolic health, including serum lipid profiles, blood pressure, endothelial function, glucoregulation, and a variety of biomarkers of inflammation and oxidative stress. These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products. Freeze-dried whole cranberry powder and a matched placebo were recently made available to investigators to facilitate such work, including interlaboratory comparability.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.