Evidence map›Paper›PMID 27422503›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2016

Associations between Sleep, Cortisol Regulation, and Diet: Possible Implications for the Risk of Alzheimer Disease.

Francesca Pistollato, Sandra Sumalla Cano, Iñaki Elio, Manuel Masias Vergara, Francesca Giampieri, Maurizio Battino

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Protein Interactome of Amyloid-β as a Therapeutic Target.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Francesca PistollatoCenter for Nutrition and Health, European University of the Atlantic (UEA), Santander, Spain;ORCID 0000-0003-0288-9539
Sandra Sumalla CanoCenter for Nutrition and Health, European University of the Atlantic (UEA), Santander, Spain; International Ibero-American University (UNINI), Campeche, Mexico; Ibero-American University Foundation (FUNIBER), Barcelona, Spain;
Iñaki ElioCenter for Nutrition and Health, European University of the Atlantic (UEA), Santander, Spain; International Ibero-American University (UNINI), Campeche, Mexico; Ibero-American University Foundation (FUNIBER), Barcelona, Spain;
Manuel Masias VergaraCenter for Nutrition and Health, European University of the Atlantic (UEA), Santander, Spain; International Ibero-American University (UNINI), Puerto Rico; and.
Francesca GiampieriCenter for Nutrition and Health, European University of the Atlantic (UEA), Santander, Spain; Department of Specialized Clinical Sciences and Dentistry, Marche Polytechnic University, Ancona, Italy m.a.battino@univpm.it f.giampieri@univpm.it.
Maurizio BattinoCenter for Nutrition and Health, European University of the Atlantic (UEA), Santander, Spain; Department of Specialized Clinical Sciences and Dentistry, Marche Polytechnic University, Ancona, Italy m.a.battino@univpm.it f.giampieri@univpm.it.
Ibero American University · MXMarche Polytechnic University · ITUniversidad Europea del Atlántico · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulation of proteinaceous amyloid β plaques and tau oligomers may occur several years before the onset of Alzheimer disease (AD). Under normal circumstances, misfolded proteins get cleared by proteasome degradation, autophagy, and the recently discovered brain glymphatic system, an astroglial-mediated interstitial fluid bulk flow. It has been shown that the activity of the glymphatic system is higher during sleep and disengaged or low during wakefulness. As a consequence, poor sleep quality, which is associated with dementia, might negatively affect glymphatic system activity, thus contributing to amyloid accumulation. The diet is another important factor to consider in the regulation of this complex network. Diets characterized by high intakes of refined sugars, salt, animal-derived proteins and fats and by low intakes of fruit and vegetables are associated with a higher risk of AD and can perturb the circadian modulation of cortisol secretion, which is associated with poor sleep quality. For this reason, diets and nutritional interventions aimed at restoring cortisol concentrations may ease sleep disorders and may facilitate brain clearance, consequentially reducing the risk of cognitive impairment and dementia. Here, we describe the associations that exist between sleep, cortisol regulation, and diet and their possible implications for the risk of cognitive impairment and AD.

Indexed as

SleepAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainCircadian RhythmCognitive DysfunctionFeeding BehaviorHumansHydrocortisoneSleep Wake DisordersWakefulnessAmyloid beta-PeptidesHydrocortisoneacidosisAlzheimer diseasecortisolglymphatic systemhippocampusnutritional interventionssleepsupplementsWestern diet

Identifiers

PMID27422503
PMCPMC4942871
OpenAlexW2465090864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.