Evidence map›Paper›PMID 27422502›Full record

SynthesisAdvances in nutrition (Bethesda, Md.)2016

The Impact of Maternal Vitamin D Status on Offspring Brain Development and Function: a Systematic Review.

Milou A Pet, Elske M Brouwer-Brolsma

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Advances in nutrition (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  7. [Vitamin D level in umbilical cord blood of late preterm infants and the effect of vitamin DZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
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  12. Vitamin D and Brain Health.Advances in experimental medicine and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Milou A PetDivision of Human Nutrition, Wageningen University, Wageningen, Netherlands; and Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Netherlands.
Elske M Brouwer-BrolsmaDivision of Human Nutrition, Wageningen University, Wageningen, Netherlands; and elske.brouwer-brolsma@wur.nl.
University Medical Center Utrecht · NLWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various studies have examined associations between maternal vitamin D (VD) deficiency and offspring health, including offspring brain health. The purpose of this review was to summarize current evidence concerning the impact of maternal VD deficiency on brain development and function in offspring. A systematic search was conducted within Medline (on Ovid) for studies published through 7 May 2015. Animal and human studies that examined associations between maternal VD status or developmental VD deficiency and offspring brain development and function were included. A total of 26 animal studies and 10 human studies met the inclusion criteria. Several animal studies confirmed the hypothesis that low prenatal VD status may affect brain morphology and physiology as well as behavioral outcomes. In humans, subtle cognitive and psychological impairments in offspring of VD-deficient mothers were observed. However, data obtained from animal and human studies provide inconclusive evidence, and results seem to depend on strain or race and age of offspring. To conclude, prenatal VD status is thought to play an important role in brain development, cognitive function, and psychological function. However, results are inconclusive; validation of these findings and investigation of underlying mechanisms are required. Thus, more investigation is needed before recommending supplementation of VD during pregnancy to promote brain health of offspring.

Indexed as

Child DevelopmentAnimalsBrainChildCognitionCognitive DysfunctionFemaleFetal DevelopmentHumansNeurodevelopmental DisordersPregnancyPregnancy ComplicationsPrenatal Exposure Delayed EffectsVitamin DVitamin D DeficiencyVitamin D25(OH)Dbraincognitiondevelopmentalmaternalneuropsychologicalprenatalvitamin D

Identifiers

PMID27422502
PMCPMC4942857
OpenAlexW2462935756

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.