ArticleAnnals of neurology2016
Deep brain stimulation and climbing fiber synaptic pathology in essential tremor.
Article in Annals of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Resting and action tremor in Parkinson's disease: pathophysiological insights from long-term STN-DBS.NPJ Parkinson's disease · 2025Article
- Clinical Heterogeneity of Essential Tremor: Understanding Neural Substrates of Action Tremor Subtypes.Cerebellum (London, England) · 2024Review
- Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Essential tremor: Clinical perspectives and pathophysiology.Journal of the neurological sciences · 2022Review
- Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.International review of neurobiology · 2022Article
- Essential tremor.Nature reviews. Disease primers · 2021Review
- Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Habituation After Deep Brain Stimulation in Tremor Syndromes: Prevalence, Risk Factors and Long-Term Outcomes.Frontiers in neurology · 2021Review
- Consensus Paper: Experimental Neurostimulation of the Cerebellum.Cerebellum (London, England) · 2019Review
- Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes.Parkinsonism & related disorders · 2018Article
- [Essential tremor: state of the art].Der Nervenarzt · 2018Review
- Animal Models of Tremor: Relevance to Human Tremor Disorders.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Review
- Postural Tremor and Ataxia Progression in Spinocerebellar Ataxias.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Article
- Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases.Acta neuropathologica · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Essential tremor (ET) patients have abnormal climbing fiber (CF) synapses in the parallel fiber territory in the cerebellum, and these abnormal CF synapses are inversely correlated with tremor severity. We therefore examined CF synaptic pathology in ET cases with and without thalamic deep brain stimulation (DBS) and assessed the association with tremor severity. We found that CF synaptic pathology was inversely correlated with tremor severity in ET cases without DBS, and this correlation disappeared in ET cases with DBS. Our data suggest that DBS might have effects in modulating excitatory synapses in ET cerebellum, in addition to its symptomatic effects on tremor. Ann Neurol 2016;80:461-465.
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Registered trials
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