ArticleThe European journal of neuroscience2016
Timing matters: open-loop stimulation does not improve overnight consolidation of word pairs in humans.
Article in The European journal of neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Memory retention following acoustic stimulation in slow-wave sleep: a meta-analytic review of replicability and measurement quality.Frontiers in sleep · 2023Pooled it
- A randomized controlled trial of alpha phase-locked auditory stimulation to treat symptoms of sleep onset insomnia.Scientific reports · 2024Trial
- Trial
- Exposure to broadband noise during non-REM sleep impairs hippocampal sharp-wave ripples and memory consolidation.Current biology : CB · 2026Article
- Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Rocking-induced sleep enhancement promotes motor learning through transcriptional and synaptic remodelling.Communications biology · 2026Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Pupil size reveals arousal level fluctuations in human sleep.Nature communications · 2025Article
- Acoustic stimulation and other emerging approaches to enhance sleep: design notes for the next generation of closed-loop neurostimulation technology.Frontiers in neuroscience · 2025Review
- The new science of sleep: From cells to large-scale societies.PLoS biology · 2024Article
- Modulation of hippocampal theta oscillations via deep brain stimulation of the parietal cortex depends on cognitive state.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Possible mechanisms to improve sleep spindles via closed loop stimulation during slow wave sleep: A computational study.PloS one · 2024Article
- Article
- Acoustic Stimulation Improves Memory and Reverses the Contribution of Chronic Sleep Deprivation to Pathology in 3xTgAD Mice.Brain sciences · 2022Article
- Effects of auditory sleep modulation approaches on brain oscillatory and cardiovascular dynamics.Sleep · 2022Article
- Article
- Investigating the effects of sleep and sleep loss on the different stages of episodic emotional memory: A narrative review and guide to the future.Frontiers in behavioral neuroscience · 2022Review
- Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats.eLife · 2021Article
- Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy.BMC neurology · 2021Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of auditory clicks during non-rapid eye movement (NREM) sleep phase-locked to the up state of the slow oscillation (closed-loop stimulation) has previously been shown to enhance the consolidation of declarative memories. We designed and applied sequences of three clicks during deep NREM sleep to achieve a quasi-phase-dependent open-loop stimulation. This stimulation was successful in eliciting slow oscillation power in the stimulation period. Although fast and slow spindle power were markedly decreased during the stimulation period, memory consolidation did not differ from control. During putative up states fast spindle power remained, however, at control levels. We conclude that concurrence of slow oscillations and fast spindles suffices to maintain memory consolidation at control levels despite an overall decreased spindle activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.