Evidence map›Paper›PMID 27422330›Full record

ReviewSeminars in cell & developmental biology2016

SNARE-mediated membrane fusion in autophagy.

Yongyao Wang, Linsen Li, Chen Hou, Ying Lai, Jiangang Long, Jiankang Liu, Qing Zhong, Jiajie Diao

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  8. Article
  9. Review
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  11. Mechanisms and roles of membrane-anchored ATG8s.Frontiers in cell and developmental biology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Cell-cell fusion in cancer: The next cancer hallmark?The international journal of biochemistry & cell biology · 2024
    Review
  19. Review
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongyao WangCenter for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Linsen LiCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; State Key Lab of Animal Nutrition, China Agricultural University, Beijing 100193, China.
Chen HouCenter for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Ying LaiDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA.
Jiangang LongCenter for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: jglong@xjtu.edu.cn.
Jiankang LiuCenter for Mitochondrial Biology and Medicine, Ministry of Education Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Qing ZhongCenter for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: qing.zhong@utsouthwestern.edu.
Jiajie DiaoDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: jiajie.diao@uc.edu.

Funding

Biochemical Dissection and Reconstitution of Autophagic Membrane FusionR01GM116908 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI ZHONG, QING · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM116908
6 · The paper itself

Abstract

Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.

Indexed as

AutophagyMembrane FusionAnimalsAutophagosomesAutophagy-Related ProteinsHumansSNARE ProteinsAutophagy-Related ProteinsSNARE ProteinsAutophagyMembrane fusionSNARE

Identifiers

PMID27422330
PMCPMC5161566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.