Evidence map›Paper›PMID 27422290›Full record

ReviewArchives of toxicology2017

Mechanisms involved in the transport of mercuric ions in target tissues.

Christy C Bridges, Rudolfs K Zalups

Abstract readReview
In one paragraph

Review in Archives of toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 179 citations in OpenAlex.

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  16. Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
  17. Article
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christy C BridgesDivision of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA, 31207, USA. bridges_cc@mercer.edu.ORCID http://orcid.org/0000-0003-1603-1445
Rudolfs K ZalupsDivision of Basic Medical Sciences, Mercer University School of Medicine, 1550 College Street, Macon, GA, 31207, USA.
Mercer University · US

Funding

TRANSPORT-TOXICITY OF INORGANIC MERCURY IN THE NEPHRONR01ES005980 · NIEHS · MERCER UNIVERSITY MACON · PI ZALUPS, RUDOLFS KARLIS · 1993 to 2006
$1.7M
METALLOTHIONEIN, MERCURY AND MONOCYTE ACTIVATIONR01ES011288 · NIEHS · MERCER UNIVERSITY MACON · PI ZALUPS, RUDOLFS KARLIS · 2002 to 2006
$1.5M
Proximal Tubular Transport of Mercury and Effects of Reduced Renal MassR15ES019991 · NIEHS · MERCER UNIVERSITY MACON · PI BRIDGES, CHRISTY C · 2011 to 2011
$471k
Role of Multidrug Resistance Proteins 2 and/or 4, and DMPS and DMSA in the RenalR03ES015511 · NIEHS · MERCER UNIVERSITY MACON · PI BRIDGES, CHRISTY C · 2007 to 2008
$145k
NIEHS NIH HHS R01 ES005980NIEHS NIH HHS R01 ES011288NIEHS NIH HHS R03 ES015511NIEHS NIH HHS R15 ES019991
6 · The paper itself

Abstract

Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are taken up by and accumulate in numerous organs, including brain, intestine, kidney, liver, and placenta. In order to understand the toxicological effects of exposure to mercury, a thorough understanding of the mechanisms that facilitate entry of mercuric ions into target cells must first be obtained. A number of mechanisms for the transport of mercuric ions into target cells and organs have been proposed in recent years. However, the ability of these mechanisms to transport mercuric ions and the regulatory features of these carriers have not been characterized completely. The purpose of this review is to summarize the current findings related to the mechanisms that may be involved in the transport of inorganic and organic forms of mercury in target tissues and organs. This review will describe mechanisms known to be involved in the transport of mercury and will also propose additional mechanisms that may potentially be involved in the transport of mercuric ions into target cells.

Indexed as

Models, BiologicalAbsorption, PhysiologicalAnimalsBiological TransportBlood-Brain BarrierEnvironmental PollutantsFemaleHumansMaleMaternal-Fetal ExchangeMercury CompoundsMercury PoisoningMethylmercury CompoundsOrganomercury CompoundsPregnancyTissue DistributionEnvironmental PollutantsMercury CompoundsMethylmercury CompoundsOrganomercury CompoundsBrainInorganic mercuryKidneyMethylmercuryTransport

Identifiers

PMID27422290
PMCPMC5226910
OpenAlexW2467052996

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.