ArticleThe journal of allergy and clinical immunology. In practice
Food Allergy Sensitization and Presentation in Siblings of Food Allergic Children.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Immunonutritional effects elicited by a novel multicomponent food supplement in children with cow's milk allergy: results from a randomized, placebo-controlled trial.Frontiers in allergy · 2026Trial
- Clinical characteristics and epidemiology of pediatric cow's milk protein allergy: a multicenter cohort study in urban China.World journal of pediatrics : WJP · 2026Article
- The Michigan Sibling Immunity Birth Study (M-SIBS): Study design protocol for a unique food allergy birth cohort.The journal of allergy and clinical immunology. Global · 2026Article
- Rising Tide of Crustacean Allergies in East Asia: a Comprehensive Review of Genetic Insights and Implications for Early Evaluation of Health Risks.Clinical reviews in allergy & immunology · 2026Review
- Strategic Directions for Advancing Equity in Food Allergy: Takeaways From CFAAR's Summit for Advancing Equity in Food Allergy.The journal of allergy and clinical immunology. In practice · 2025Article
- Targeting Food Allergy with Probiotics.Advances in experimental medicine and biology · 2024Review
- Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases.Allergy, asthma & immunology research · 2023Review
- Multi-omics profiling approach in food allergy.The World Allergy Organization journal · 2023Review
- Trends in the contributions of atopic family history to pediatric food sensitization and allergy.Frontiers in pediatrics · 2022Article
- What is causing the rise in food allergy? A narrative review of risk factors for the development of food allergy in infants and children.Frontiers in allergy · 2022Article
- Current insights into the genetics of food allergy.The Journal of allergy and clinical immunology · 2021Review
- Stem Cell Factor Neutralization Protects From Severe Anaphylaxis in a Murine Model of Food Allergy.Frontiers in immunology · 2021Article
- Advances and novel developments in environmental influences on the development of atopic diseases.Allergy · 2020Review
- Possible Role of Environmental Factors in the Development of Food Allergies.Clinical reviews in allergy & immunology · 2019Review
- Prevalence of Self-Reported Food Allergy in Six Regions of Inner Mongolia, Northern China: A Population-Based Survey.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- The Genetics of Food Allergy.Current allergy and asthma reports · 2018Review
- Analysis of a Large Standardized Food Challenge Data Set to Determine Predictors of Positive Outcome Across Multiple Allergens.Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMany parents of food allergic children have concerns about the development of food allergies in their other children.
objectiveWe sought to determine prevalence of food sensitization and clinical food allergy among siblings of food allergic children.
methodsTwo thousand eight hundred and thirty-four children were enrolled in the Chicago Family Cohort Food Allergy study. One thousand one hundred and twenty children (ages 0-21 years) with a food allergy (defined by a reported reaction history and evidence of food-specific IgE or skin prick test) and at least 1 biological sibling were included in this study.
resultsAmong siblings of children with food allergy, 33.4% had no sensitization and no clinical symptoms to food. Fifty-three percent had a positive food serum-specific IgE or skin prick test, but no reported symptoms of food allergy. Only 13.6% of siblings were both sensitized and clinically reactive to the same food. Milk allergy was the most common allergy among siblings (5.9%), followed by egg allergy (4.4%) and peanut allergy (3.7%).
conclusionsIn a large cohort of food allergic families, only a small proportion of siblings were both sensitized and clinically reactive to a food. Sensitization without reactivity was common among siblings. Testing for food allergy in siblings without a history of clinical reactivity appears to be unjustified. Screening may lead to negative consequences related to potential misdiagnosis and unnecessary avoidance of a food. More data are needed to determine the absolute risk of food allergy development in siblings of food allergic children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.