Evidence map›Paper›PMID 27421894›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2016

Stimulant drug effects on touchscreen automated paired-associates learning (PAL) in rats.

Corinna Roschlau, Angeline Votteler, Wolfgang Hauber

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Corinna RoschlauDepartment Animal Physiology, University of Stuttgart, D-70550 Stuttgart, Germany.
Angeline VottelerDepartment Animal Physiology, University of Stuttgart, D-70550 Stuttgart, Germany.
Wolfgang HauberDepartment Animal Physiology, University of Stuttgart, D-70550 Stuttgart, Germany hauber@bio.uni-stuttgart.de.
University of Stuttgart · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here we tested in rats effects of the procognitive drugs modafinil and methylphenidate on post-acquisition performance in an object-location paired-associates learning (PAL) task. Modafinil (32; 64 mg/kg) was without effect, while higher (9 mg/kg) but not lower (4.5 mg/kg) doses of methylphenidate impaired PAL performance. Likewise, higher but not lower doses of amphetamine (0.4; 0.8 mg/kg) and MK-801 (0.08; 0.12 mg/kg) decreased PAL performance. Impaired PAL performance induced by methylphenidate, amphetamine, and MK801 most likely reflects compromised cognitive function, e.g., retrieval of learned paired associates. Our data suggest that stimulant drugs such as methylphenidate and modafinil might not facilitate performance in hippocampus-related cognitive tasks.

Indexed as

AmphetamineAnimalsBenzhydryl CompoundsCentral Nervous System StimulantsConditioning, OperantDizocilpine MaleateDose-Response Relationship, DrugMaleMethylphenidateModafinilNootropic AgentsPaired-Associate LearningRatsWakefulness-Promoting AgentsAmphetamineBenzhydryl CompoundsCentral Nervous System StimulantsDizocilpine MaleateMethylphenidateModafinilNootropic AgentsWakefulness-Promoting Agents

Identifiers

PMID27421894
PMCPMC4947238
OpenAlexW2467425381

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.