Evidence map›Paper›PMID 27421735›Full record

ArticlePurinergic signalling2016

UDP-glucose promotes neutrophil recruitment in the lung.

Juliana I Sesma, Clarissa D Weitzer, Alessandra Livraghi-Butrico, Hong Dang, Scott Donaldson, Neil E Alexis, Kenneth A Jacobson, T Kendall Harden, Eduardo R Lazarowski

Open access · bronzeAbstract read
In one paragraph

Article in Purinergic signalling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 64 citations in OpenAlex.

  1. Urinary UDP-sugars provide actionable prediction of acute kidney injury in cardiac surgery patients.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. P2YActa pharmaceutica Sinica. B · 2025
    Article
  9. Design, Synthesis and Anti-Inflammation Evaluation ofDrug design, development and therapy · 2025
    Article
  10. Observational
  11. Article
  12. Article
  13. Exploring bias in platelet P2YBritish journal of pharmacology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Juliana I SesmaMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina School of Medicine, 6007 Thurston-Bowles Building, CB 7248, Chapel Hill, NC, 27599-7248, USA.
Clarissa D WeitzerDepartment of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Alessandra Livraghi-ButricoMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina School of Medicine, 6007 Thurston-Bowles Building, CB 7248, Chapel Hill, NC, 27599-7248, USA.
Hong DangMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina School of Medicine, 6007 Thurston-Bowles Building, CB 7248, Chapel Hill, NC, 27599-7248, USA.
Scott DonaldsonMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina School of Medicine, 6007 Thurston-Bowles Building, CB 7248, Chapel Hill, NC, 27599-7248, USA.
Neil E AlexisCenter for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
T Kendall HardenDepartment of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Eduardo R LazarowskiMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina School of Medicine, 6007 Thurston-Bowles Building, CB 7248, Chapel Hill, NC, 27599-7248, USA. eduardo_lazarowski@med.unc.edu.
University of North Carolina at Chapel Hill · USLung Institute · USNational Institutes of Health · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
The Mucus Transport Apparatus: Why Two Layers?P50HL084934 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2006 to 2010
$15.6M
Purinergic Control of CFTR-ENaC Interactions in Alveolar EpitheliaP01HL110873 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOUCHER, RICHARD CHARLES · 2012 to 2016
$10.7M
Development Of P2Y Receptor LigandsZIADK031116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$8.9M
P2Y-PURINERGIC RECEPTORSR01GM038213 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARDEN, T KENDALL · 1987 to 2012
$3.9M
Airway Biology of Acute Asthma: Translational StudiesR01HL080337 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2005 to 2008
$2.0M
Intramural NIH HHS ZIA DK031116NHLBI NIH HHS P01 HL110873NHLBI NIH HHS P50 HL084934NHLBI NIH HHS R01 HL080337NIDDK NIH HHS P30 DK065988NIGMS NIH HHS R01 GM038213
6 · The paper itself

Abstract

In addition to their role in glycosylation reactions, UDP-sugars are released from cells and activate widely distributed cell surface P2Y

Indexed as

Adenosine TriphosphateAdultAnimalsCystic FibrosisCytokinesDisease Models, AnimalFemaleHumansLungMaleMiceNeutrophil InfiltrationNeutrophilsSputumTracheaUridine Diphosphate GlucoseAdenosine TriphosphateCytokinesUridine Diphosphate GlucoseLung inflammationNeutrophilsP2Y14 receptorPurinergic receptorsUDP-glucose

Identifiers

PMID27421735
PMCPMC5124001
OpenAlexW2468258931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.