Evidence map›Paper›PMID 27421714›Full record

ArticleMuscle & nerve2017

Impact of TIEG1 on the structural properties of fast- and slow-twitch skeletal muscle.

Malek Kammoun, Sandra Meme, William Meme, Malayannan Subramaniam, John R Hawse, Francis Canon, Sabine F Bensamoun

Open access · bronzeAbstract read
In one paragraph

Article in Muscle & nerve, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Deciphering the Role ofJournal of biomedical science and engineering · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Malek KammounUniversité de Technologie de Compiègne, Centre de Recherches de Royallieu, Laboratoire de Biomécanique et de BioIngénierie, UMR CNRS 7338, BP 20529, 60205, Compiègne Cedex, France.
Sandra MemeCentre de Biophysique Moléculaire, CNRS UPR4301, Orléans, France.
William MemeCentre de Biophysique Moléculaire, CNRS UPR4301, Orléans, France.
Malayannan SubramaniamDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.
John R HawseDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.
Francis CanonUniversité de Technologie de Compiègne, Centre de Recherches de Royallieu, Laboratoire de Biomécanique et de BioIngénierie, UMR CNRS 7338, BP 20529, 60205, Compiègne Cedex, France.
Sabine F BensamounUniversité de Technologie de Compiègne, Centre de Recherches de Royallieu, Laboratoire de Biomécanique et de BioIngénierie, UMR CNRS 7338, BP 20529, 60205, Compiègne Cedex, France.
Université de Technologie de Compiègne · FRMayo Clinic · USCentre de Biophysique Moléculaire · FRCentre National de la Recherche Scientifique · FR

Funding

Role of a TGF-? Regulated Gene in Human and Mouse Osteoblasts and SkeletonR01DE014036 · NIDCR · MAYO CLINIC ROCHESTER · PI HAWSE, JOHN R., SUBRAMANIAM, MALAYANNAN · 2001 to 2016
$4.7M
Role of aTGF-beta Regulated Gene in human and mouse osteoblasts and skeletonR56DE014036 · NIDCR · MAYO CLINIC ROCHESTER · PI SPELSBERG, THOMAS C · 2007 to 2007
$352k
NIDCR NIH HHS R01 DE014036NIDCR NIH HHS R56 DE014036
6 · The paper itself

Abstract

introductionTransforming growth factor-beta (TGF-β)-inducible early gene-1 (TIEG1) is a transcription factor that is highly expressed in skeletal muscle. The purpose of this study was to characterize the structural properties of both fast-twitch (EDL) and slow-twitch (soleus) muscles in the hindlimb of TIEG1-deficient (TIEG1

methodsTen slow and 10 fast muscles were analyzed from TIEG1

resultsMRI-TA could discriminate between WT slow and fast muscles. Deletion of the TIEG1 gene led to changes in the texture profile within both muscle types. Specifically, muscle isolated from TIEG1

conclusionsWe demonstrated that TIEG1 plays an important role in the structural properties of skeletal muscle. This study further implicates important roles for TIEG1 in the development of skeletal muscle and suggests that defects in TIEG1 expression and/or function may be associated with muscle disease. Muscle Nerve 55: 410-416, 2017.

Indexed as

AnimalsDNA-Binding ProteinsEarly Growth Response Transcription FactorsFemaleHindlimbKruppel-Like Transcription FactorsMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMice, TransgenicMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchPrincipal Component AnalysisRNA, MessengerTranscription FactorsDNA-Binding ProteinsEarly Growth Response Transcription FactorsKLF10 protein, mouseKruppel-Like Transcription FactorsRNA, MessengerTranscription FactorsmiceMRIslow and fast musclesstructural propertiestexture analysisTIEG1

Identifiers

PMID27421714
PMCPMC5239761
OpenAlexW2509108345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.