Evidence map›Paper›PMID 27421618›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2016

Modifiable Risk Factors and Brain Positron Emission Tomography Measures of Amyloid and Tau in Nondemented Adults with Memory Complaints.

David A Merrill, Prabha Siddarth, Cyrus A Raji, Natacha D Emerson, Florangel Rueda, Linda M Ercoli, Karen J Miller, Helen Lavretsky, Laurel M Harris, Alison C Burggren and 3 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00355498 (Amyloid Plaque and Tangle Imaging in Aging and Dementia), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00355498 completednot on this map

Amyloid Plaque and Tangle Imaging in Aging and Dementia

TypeobservationalSponsorUniversity of California, Los AngelesRan2005 to 2010Enrolled170ConditionsMemory Disorders, Alzheimer's Disease
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Dietary pattern in relation to the risk of Alzheimer's disease: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Pooled it
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  18. Obstructive Sleep Apnea and the Risk of Cognitive Decline in Older Adults.American journal of respiratory and critical care medicine · 2019
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

David A MerrillDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA. Electronic address: dmerrill@mednet.ucla.edu.
Prabha SiddarthDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
Cyrus A RajiDepartment of Radiology, UCLA Health System, David Geffen School of Medicine, University of California, Los Angeles, CA.
Natacha D EmersonDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
Florangel RuedaDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
Linda M ErcoliDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
Karen J MillerDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
Helen LavretskyDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
Laurel M HarrisCenter for Cognitive Neurosciences, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA.
Alison C BurggrenCenter for Cognitive Neurosciences, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA.
Susan Y BookheimerCenter for Cognitive Neurosciences, Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, CA.
Jorge R BarrioDepartment of Molecular and Medical Pharmacology, Center for Health Sciences, University of California, Los Angeles, CA.
Gary W SmallDivision of Geriatric Psychiatry, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine, and Longevity Center, University of California, Los Angeles, CA.
University of California, Los Angeles · USOklahoma State University Center for Health Sciences · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BREDESEN, DALE E. · 1999 to 2014
$25.9M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
VISUALIZING BRAIN A-BETA, TAU /SEROTONIN RECEPTOR DENSITP01AG025831 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 2005 to 2010
$7.0M
FUNCTIONAL MRI FOR EARLY DIAGNOSIS OF ALZHEIMER'SR01AG013308 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOOKHEIMER, SUSAN Y · 1995 to 2011
$4.5M
Methylphenidate Use to Improve Outcomes in Geriatric DepressionR01MH077650 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2008 to 2012
$1.8M
Effects of heavy adolescent cannabis use on brain morphology in agingK01DA034728 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BURGGREN, ALISON CLEMENTS · 2013 to 2017
$776k
Tai Chi Chih: Complementary Use to Achieve Remission in Geriatric DepressionR21AT003480 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2007 to 2009
$608k
UCLA ALZHEIMERS DISEASE CENTERP30AG010123 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CUMMINGS, JEFFREY L. · 1991 to 1998
–
NCATS NIH HHS UL1 TR000124NCCIH NIH HHS R21 AT003480NCRR NIH HHS M01 RR000865NIA NIH HHS P01 AG025831NIA NIH HHS P30 AG010123NIA NIH HHS P30 AG028748NIA NIH HHS P50 AG016570NIA NIH HHS R01 AG013308NIDA NIH HHS K01 DA034728NIMH NIH HHS R01 MH077650
6 · The paper itself

Abstract

objectiveExercise and diet impact body composition, but their age-related brain effects are unclear at the molecular imaging level. To address these issues, the authors determined whether body mass index (BMI), physical activity, and diet relate to brain positron emission tomography (PET) of amyloid plaques and tau tangles using 2-(1-(6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl)ethylidene)malononitrile (FDDNP).

methodsVolunteers (N = 44; mean age: 62.6 ± 10.7 years) with subjective memory impairment (N = 24) or mild cognitive impairment (MCI; N = 20) were recruited by soliciting for memory complaints. Levels of physical activity and extent of following a Mediterranean-type diet were self-reported. FDDNP-PET scans assessed plaque/tangle binding in Alzheimer disease-associated regions (frontal, parietal, medial and lateral temporal, posterior cingulate). Mixed models controlling for known covariates examined BMI, physical activity, and diet in relation to FDDNP-PET.

resultsMCI subjects with above normal BMI (>25) had higher FDDNP-PET binding compared with those with normal BMI (1.11(0.03) versus 1.08(0.03), ES = 1.04, t(35) = 3.3, p = 0.002). Greater physical activity was associated with lower FDDNP-PET binding in MCI subjects (1.07(0.03) versus 1.11(0.03), ES = 1.13, t(35) = -3.1, p = 0.004) but not in subjects with subjective memory impairment (1.07(0.03) versus 1.07(0.03), ES = 0.02, t(35) = -0.1, p = 0.9). Healthier diet related to lower FDDNP-PET binding, regardless of cognitive status (1.07(0.03) versus 1.09(0.02), ES = 0.72, t(35) = -2.1, p = 0.04).

conclusionThese preliminary findings are consistent with a relationship between risk modifiersand brain plaque/tangle deposition in nondemented individuals and supports maintenance of normal body weight, regular physical activity, and healthy diet to protect the brain during aging. (clinicaltrials.gov; NCT00355498).

Indexed as

AgingBrainCognitive DysfunctionExerciseMemory DisordersSelf-AssessmentAgedDiet, MediterraneanFemaleHumansMaleMiddle AgedNeurofibrillary TanglesPlaque, AmyloidPositron-Emission TomographyProtective FactorsAlzheimer diseaseexerciseFDDNPPET

Identifiers

PMID27421618
PMCPMC5003686
OpenAlexW2382560093

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.