ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016
Decreased hippocampal metabolism in high-amyloid mild cognitive impairment.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Neuropsychological and neuroimaging characteristics of patients with mild cognitive impairment and negative-amyloid deposition.Frontiers in neurology · 2025Article
- Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis.Frontiers in pharmacology · 2025Article
- Cisplatin induces hippocampal neurotoxicity and cognitive impairment in rats through neuroinflammation, oxidative stress, and overexpression of glutamatergic receptors mRNA.Frontiers in pharmacology · 2025Article
- Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Distinct effects of beta-amyloid and tau on cortical thickness in cognitively healthy older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Crosstalk between Depression and Dementia with Resting-State fMRI Studies and Its Relationship with Cognitive Functioning.Biomedicines · 2021Review
- Hippocampal Functional Connectivity and Memory Performance After Exercise Intervention in Older Adults with Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2021Article
- EEG-fMRI Signal Coupling Is Modulated in Subjects With Mild Cognitive Impairment and Amyloid Deposition.Frontiers in aging neuroscience · 2021Article
- Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults.NeuroImage · 2020Article
- A New Rat Model of Chronic Cerebral Hypoperfusion Resulting in Early-Stage Vascular Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- Longitudinal Association of Depression Symptoms With Cognition and Cortical Amyloid Among Community-Dwelling Older Adults.JAMA network open · 2019Article
- Altered Directed Functional Connectivity of the Hippocampus in Mild Cognitive Impairment and Alzheimer's Disease: A Resting-State fMRI Study.Frontiers in aging neuroscience · 2019Article
- Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients.Alzheimer's & dementia (Amsterdam, Netherlands) · 2018Article
- Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden.Neurology · 2017Article
- Article
- Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.Annals of neurology · 2017Article
- Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults.Journal of Alzheimer's disease : JAD · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
introductionHippocampal volume (HV), cortical metabolism, and thickness are decreased in mild cognitive impairment (MCI). Hippocampal metabolism (HM) studies comparing MCI and clinically normal (CN) elderly gave inconsistent results. As hippocampus is a key region in Alzheimer's disease, we hypothesized that HM is specifically decreased in high-amyloid MCI.
methodsOverall, 250 CN and 45 MCI underwent three-dimensional magnetic resonance imaging, fludeoxyglucose-positron emission tomography, and fluorodeoxyglucose-positron emission tomography (PET), and Pittsburgh Compound B (PiB) PET. We investigated the interaction between clinical and amyloid status on HM, HV, cortical metabolism, and thickness using linear models, covarying age, gender, and education. Analyses were conducted with and without correction for multiple comparisons and for partial volume effects.
resultsVolume-adjusted HM was decreased in high-amyloid MCI but close to normal in low-amyloid MCI and in high-amyloid CN. Both MCI groups had hippocampal atrophy, although less severe in low-amyloid MCI. High-amyloid CN and high-amyloid MCI had cortical hypometabolism. DISCUSSION: HM is decreased when both cognitive impairment and amyloid are present.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.