ArticleNeuroscience2016
Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors.
Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- PVN-NAc Shell-VP Circuit OT and OTR Neurons Regulate Pair Bonding via D2R and D1R.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety.Science (New York, N.Y.) · 2025Article
- A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2024Review
- Stress-impaired reward pathway promotes distinct feeding behavior patterns.Frontiers in neuroscience · 2024Article
- Article
- Somatodendritic Release of Cholecystokinin Potentiates GABAergic Synapses Onto Ventral Tegmental Area Dopamine Cells.Biological psychiatry · 2023Article
- Cocaine's effects on the reactivity of the medial prefrontal cortex to ventral tegmental area stimulation: optical imaging study in mice.Addiction (Abingdon, England) · 2022Article
- Review
- IProgress in neuro-psychopharmacology & biological psychiatry · 2022Article
- VTA MC3R neurons control feeding in an activity- and sex-dependent manner in mice.Neuropharmacology · 2021Article
- Chemogenetic Activation of Mesoaccumbal Gamma-Aminobutyric Acid Projections Selectively Tunes Responses to Predictive Cues When Reward Value Is Abruptly Decreased.Biological psychiatry · 2021Article
- Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice.Frontiers in cellular neuroscience · 2021Article
- Linking Ethanol-Addictive Behaviors With Brain Catecholamines: Release Pattern Matters.Frontiers in behavioral neuroscience · 2021Review
- Bidirectional Control of Alcohol-drinking Behaviors Through Locus Coeruleus Optoactivation.Neuroscience · 2020Article
- Opposite Consequences of Tonic and Phasic Increases in Accumbal Dopamine on Alcohol-Seeking Behavior.iScience · 2020Article
- Optogenetic investigation of neural mechanisms for alcohol-use disorder.Alcohol (Fayetteville, N.Y.) · 2019Review
- Sex-dependent regulation of social reward by oxytocin: an inverted U hypothesis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Latency to Reward Predicts Social Dominance in Rats: A Causal Role for the Dopaminergic Mesolimbic System.Frontiers in behavioral neuroscience · 2019Article
- Viral vector strategies for investigating midbrain dopamine circuits underlying motivated behaviors.Pharmacology, biochemistry, and behavior · 2018Review
- Challenges to Body Fluid Homeostasis Differentially Recruit Phasic Dopamine Signaling in a Taste-Selective Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Recent optogenetic studies demonstrated that phasic dopamine release in the nucleus accumbens may play a causal role in multiple aspects of natural and drug reward-related behaviors. The role of tonic dopamine release in reward consummatory behavior remains unclear. The current study used a combinatorial viral-mediated gene delivery approach to express ChR2 on mesolimbic dopamine neurons in rats. We used optical activation of this dopamine circuit to mimic tonic dopamine release in the nucleus accumbens and to explore the causal relationship between this form of dopamine signaling within the ventral tegmental area (VTA)-nucleus accumbens projection and consumption of a natural reward. Using a two bottle choice paradigm (sucrose vs. water), the experiments revealed that tonic optogenetic stimulation of mesolimbic dopamine transmission significantly decreased reward consummatory behaviors. Specifically, there was a significant decrease in the number of bouts, licks and amount of sucrose obtained during the drinking session. Notably, activation of VTA dopamine cell bodies or dopamine terminals in the nucleus accumbens resulted in identical behavioral consequences. No changes in water intake were evident under the same experimental conditions. Collectively, these data demonstrate that tonic optogenetic stimulation of VTA-nucleus accumbens dopamine release is sufficient to inhibit reward consummatory behavior, possibly by preventing this circuit from engaging in phasic activity that is thought to be essential for reward-based behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.