ArticleThe Pediatric infectious disease journal2016
Emerging Streptococcus pneumoniae Strains Colonizing the Nasopharynx in Children After 13-valent Pneumococcal Conjugate Vaccination in Comparison to the 7-valent Era, 2006-2015.
Article in The Pediatric infectious disease journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Antibiotic treatment to prevent pediatric acute otitis media infectious complications: A meta-analysis.PloS one · 2024Pooled it
- Variability in Vaccine Response and Trajectory in Early Childhood and Association With Demographic Variables, Antibiotic Exposure, and Infection Proneness.The Journal of infectious diseases · 2025Article
- Pneumococci Isolated From Children in Community-Based Practice Differ From Isolates Identified by Population- and Laboratory-Based Invasive Disease Surveillance.The Journal of infectious diseases · 2024Article
- Variability of Vaccine Responsiveness in Young Children.The Journal of infectious diseases · 2024Article
- High frequencies of nonviral colds and respiratory bacteria colonization among children in rural Western Uganda.Frontiers in pediatrics · 2024Article
- Otitis media: recent advances in otitis media vaccine development and model systems.Frontiers in microbiology · 2024Review
- Genomic classification and antimicrobial resistance profiling of Streptococcus pneumoniae and Haemophilus influenza isolates associated with paediatric otitis media and upper respiratory infection.BMC infectious diseases · 2023Article
- Antibiotics for lower respiratory tract infection in children presenting in primary care: ARTIC-PC RCT.Health technology assessment (Winchester, England) · 2023Article
- In Silico Subtractive Proteomics and Molecular Docking Approaches for the Identification of Novel Inhibitors againstLife (Basel, Switzerland) · 2023Article
- Key features of pneumococcal isolates recovered in Central and Northwestern Russia in 2011-2018 determined through whole-genome sequencing.Microbial genomics · 2022Article
- Changes in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between 2006 and 2018.Scientific reports · 2022Article
- Amoxicillin-resistanteLife · 2022Article
- Pneumococcal Surface Protein A-Hybrid Nanoparticles Protect Mice from Lethal Challenge after Mucosal Immunization Targeting the Lungs.Pharmaceutics · 2022Article
- Dynamic changes in otopathogens colonizing the nasopharynx and causing acute otitis media in children after 13-valent (PCV13) pneumococcal conjugate vaccination during 2015-2019.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Bacteria and viruses in the upper respiratory tract of Congolese children with radiologically confirmed pneumonia.BMC infectious diseases · 2021Article
- Comparison of specific in-vitro virulence gene expression and innate host response in locally invasive vs colonizer strains of Streptococcus pneumoniae.Medical microbiology and immunology · 2021Article
- Rising Pneumococcal Antibiotic Resistance in the Post-13-Valent Pneumococcal Conjugate Vaccine Era in Pediatric Isolates From a Primary Care Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Transition of Serotype 35B Pneumococci From Commensal to Prevalent Virulent Strain in Children.Frontiers in cellular and infection microbiology · 2021Article
- Nasopharyngeal Carriage in Children After the Introduction of Generalized Infant Pneumococcal Conjugate Vaccine Immunization in Germany.Frontiers in medicine · 2021Article
- COVID-19 Pandemic Impact on Respiratory Infectious Diseases in Primary Care Practice in Children.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAfter introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, emergence of replacement serotypes occurred, leading to the introduction of a 13-valent pneumococcal conjugate vaccine (PCV13) in 2010 that contained all PCV7 serotypes plus 6 additional serotypes (1, 3, 5, 6A, 7F and 19A). Here, we describe a 9-year prospective, longitudinal study characterizing Streptococcus pneumoniae strains colonizing the nasopharynx (NP) of young children based on serotype, sequence type (ST) and antibiotic susceptibility during the PCV7 and PCV13 eras.
methodsNP samples were obtained for pneumococcal identification from prospectively followed children at 6, 9, 12, 15, 18, 24 and 30 months of age. A total of 1072 visits during the PCV7 era (June 2006 to September 2010) and 2044 visits during the PCV13 era (October 2010 to September 2015) were included from 665 children. Serotyping and multilocus sequence typing types of Streptococcus pneumoniae isolates were evaluated along with their antibiotic resistance pattern.
resultsA total of 1045 Streptococcus pneumoniae were isolated; 350 during the PCV7 era and 685 during the PCV13 era. The most common serotypes identified during the PCV7 era were 19A and 23B compared with 35B, 23B and 21 in PCV13 era. Serotypes 15A/B/C emerged in equal proportion during the PCV13 era. Serotypes 16 and 20 were only observed in the PCV13 era. NP carriage of 19A persisted 5 years after PCV13 introduction (5% of all isolates). Multilocus ST 199 remained a dominant ST during both the PCV7 and PCV13 eras, and ST558 and ST62 emerged after PCV13. Antibiotic resistance to penicillin, ceftriaxone, cefotaxime, erythromycin, tetracycline and trimethoprim/sulfamethoxazole significantly decreased from the PCV7 to the PCV13 era.
conclusionsSerotypes 35B, 23B, 21 and 15A/B/C rapidly emerged as NP colonizers in the early PCV13 era. Genetically divergent strains with ST558 and ST62 emerged. Resistance to common antibiotics declined after the introduction of PCV13.
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