Evidence map›Paper›PMID 27420564›Full record

ArticleCurrent eye research2017

No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration.

Nicholas A Popp, Elvira Agrón, Gregory S Hageman, Jingsheng Tuo, Emily Y Chew, Chi-Chao Chan

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current eye research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicholas A Poppa Immunopathology Section, Laboratory of Immunology , National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
Elvira Agrónb Division of Epidemiology and Clinical Applications , National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
Gregory S Hagemanc Department of Ophthalmology and Visual Sciences , University of Utah, John A. Moran Eye Center , Salt Lake City , Utah , USA.
Jingsheng Tuoa Immunopathology Section, Laboratory of Immunology , National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
Emily Y Chewb Division of Epidemiology and Clinical Applications , National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
Chi-Chao Chana Immunopathology Section, Laboratory of Immunology , National Eye Institute, National Institutes of Health , Bethesda , Maryland , USA.
National Institutes of Health · USUniversity of Utah · US

Funding

Age-Related Eye Disease Follow-up Study (AREDS) Follow-up StudyZIAEY000489 · NEI · NATIONAL EYE INSTITUTE · PI CHEW, EMILY Y · 2009 to 2025
$639k
Intramural NIH HHS ZIA EY000489
6 · The paper itself

Abstract

purposeSince some studies have reported differences in the association of age-related macular degeneration (AMD) with biological sex, we set out to determine whether the difference in the disease susceptibility is afforded by common single nucleotide polymorphisms (SNPs) associated with AMD.

methodsWe genotyped 2067 Caucasian subjects from the Age-Related Eye Disease Study cohort for commonly associated AMD SNPs, including those in CFH (rs1061170, rs1410996, and rs3766404), ARMS2 (rs10490924), and C3 (rs2230199) using either a Sequenom MassARRAY MALDI-TOF mass spectrometer or using Taqman genotyping reagents. A Cox proportional hazards model was used to determine the effect of genotype, age, sex, and smoking status on the development of AMD.

resultsAll tested SNPs genotyped are associated strongly with AMD (p < 0.0001), in concordance with previous studies. However, we found no observable differences in any of the SNPs studied when categorized by sex. Interactions between SNPs and sex were found to be not statistically significant (p = 0.38-0.79).

conclusionsThe difference between male and female incidence of AMD is not explained by the most commonly AMD-associated SNPs, though it does not exclude the possibility that other, less common SNPs contribute to this difference.

Indexed as

Polymorphism, Single NucleotideAgedComplement C3Complement Factor HDNAEye ProteinsFemaleGenotypeHumansMaleMorbidityProteinsRisk FactorsSex DistributionSex FactorsUnited StatesARMS2 protein, humanComplement C3Complement Factor HDNAEye ProteinsProteinsAge-related macular degenerationgeneticssexSNPs

Identifiers

PMID27420564
PMCPMC8324397
OpenAlexW2462108915

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.