ReviewLife (Basel, Switzerland)2016
Constructive Approaches for Understanding the Origin of Self-Replication and Evolution.
Review in Life (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Applications of phage-derived RNA-based technologies in synthetic biology.Synthetic and systems biotechnology · 2020Review
- Thresholds in Origin of Life Scenarios.iScience · 2020Review
- Investigating Prebiotic Protocells for A Comprehensive Understanding of the Origins of Life: A Prebiotic Systems Chemistry Perspective.Life (Basel, Switzerland) · 2019Review
- Is Research on "Synthetic Cells" Moving to the Next Level?Life (Basel, Switzerland) · 2018Article
- Efficient Arrangement of the Replication Fork Trap for In Vitro Propagation of Monomeric Circular DNA in the Chromosome-Replication Cycle Reaction.Life (Basel, Switzerland) · 2018Article
- Self-replication of circular DNA by a self-encoded DNA polymerase through rolling-circle replication and recombination.Scientific reports · 2018Article
- Automated in vitro evolution of a translation-coupled RNA replication system in a droplet flow reactor.Scientific reports · 2018Article
- Conceptualizing the origin of life in terms of evolution.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Review
- Translation activity of chimeric ribosomes composed ofBiochemistry and biophysics reports · 2017Article
- Novel directions in molecular systems design: The case of light-transducing synthetic cells.Communicative & integrative biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mystery of the origin of life can be divided into two parts. The first part is the origin of biomolecules: under what physicochemical conditions did biomolecules such as amino acids, nucleotides, and their polymers arise? The second part of the mystery is the origin of life-specific functions such as the replication of genetic information, the reproduction of cellular structures, metabolism, and evolution. These functions require the coordination of many different kinds of biological molecules. A direct strategy to approach the second part of the mystery is the constructive approach, in which life-specific functions are recreated in a test tube from specific biological molecules. Using this approach, we are able to employ design principles to reproduce life-specific functions, and the knowledge gained through the reproduction process provides clues as to their origins. In this mini-review, we introduce recent insights gained using this approach, and propose important future directions for advancing our understanding of the origins of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.