ArticleInternational journal of molecular sciences2016
Nanodiamonds for Medical Applications: Interaction with Blood in Vitro and in Vivo.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Laser-based assessment of nanoparticle effects on RBC aggregation: an in vitro study.Biomedical optics express · 2026Article
- Profiling High-Abundance Serum Proteins in the Corona of Nanodiamonds Using Mass Spectrometry.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Integrating Proteomics and Predictive Model: Elucidating the Role of Aminated Nanodiamonds in Suppressing Prostate Cancer Growth.ACS omega · 2026Article
- Comprehensive analysis of electrochemical biosensors for early ovarian cancer detection.RSC advances · 2024Review
- Release dynamics of nanodiamonds created by laser-driven shock-compression of polyethylene terephthalate.Scientific reports · 2024Article
- Nanodiamonds: Next generation nano-theranostics for cancer therapy.Cancer letters · 2024Review
- Carbon-Based Nanostructures as Emerging Materials for Gene Delivery Applications.Pharmaceutics · 2024Review
- The Structure Properties of Carbon Materials Formed in 2,4,6-Triamino-1,3,5-Trinitrobenzene Detonation: A Theoretical Insight for Nucleation of Diamond-like Carbon.International journal of molecular sciences · 2023Article
- Unraveling the nature of nano-diamonds and silica in a catheterized tapered artery: highlights into hydrophilic traits.Scientific reports · 2023Article
- Increasing the effect of annonacin using nanodiamonds to inhibit breast cancer cells growth in rats (Heliyon · 2022Article
- Characterization of Carbon Nanostructures by Photoelectron Spectroscopies.Materials (Basel, Switzerland) · 2022Review
- Nanodiamond-Induced Thrombocytopenia in Mice Involve P-Selectin-Dependent Nlrp3 Inflammasome-Mediated Platelet Aggregation, Pyroptosis and Apoptosis.Frontiers in immunology · 2022Article
- Nanodiamond as a Cytokine Sponge in Infectious Diseases.Frontiers in bioengineering and biotechnology · 2022Article
- Raman Spectroscopic Study of TiOMaterials (Basel, Switzerland) · 2021Article
- pH Sensitive Dextran Coated Fluorescent Nanodiamonds as a Biomarker for HeLa Cells Endocytic Pathway and Increased Cellular Uptake.Nanomaterials (Basel, Switzerland) · 2021Article
- Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System.Pharmaceutics · 2020Article
- Effects of Fluorescent Diamond Particles FDP-NV-800nm on Essential Biochemical Functions of Primary Human Umbilical Vein Cells and Human Hepatic Cell Line, HepG-2 in vitro (Part VI): Acute Biocompatibility Studies.Nanotechnology, science and applications · 2020Article
- Why nanodiamond carriers manage to overcome drug resistance in cancer.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Heavy Pnictogenium Cations as Transmembrane Anion Transporters in Vesicles and Erythrocytes.Chem · 2019Article
- Knockdown of microRNA-135b in Mammary Carcinoma by Targeted Nanodiamonds: Potentials and Pitfalls of In Vivo Applications.Nanomaterials (Basel, Switzerland) · 2019Article
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6 authors.
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Abstract
Nanodiamonds (ND) have emerged to be a widely-discussed nanomaterial for their applications in biological studies and for medical diagnostics and treatment. The potentials have been successfully demonstrated in cellular and tissue models in vitro. For medical applications, further in vivo studies on various applications become important. One of the most challenging possibilities of ND biomedical application is controllable drug delivery and tracing. That usually assumes ND interaction with the blood system. In this work, we study ND interaction with rat blood and analyze how the ND surface modification and coating can optimize the ND interaction with the blood. It was found that adsorption of a low concentration of ND does not affect the oxygenation state of red blood cells (RBC). The obtained in vivo results are compared to the results of in vitro studies of nanodiamond interaction with rat and human blood and blood components, such as red blood cells and blood plasma. An in vivo animal model shows ND injected in blood attach to the RBC membrane and circulate with blood for more than 30 min; and ND do not stimulate an immune response by measurement of proinflammatory cytokine TNF-α with ND injected into mice via the caudal vein. The results further confirm nanodiamonds' safety in organisms, as well as the possibility of their application without complicating the blood's physiological conditions.
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