ArticleBiosensors & bioelectronics2016
Electrochemical monitoring-on-chip (E-MoC) of HIV-infection in presence of cocaine and therapeutics.
Article in Biosensors & bioelectronics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Nanotechnology-Enabled Biosensors: A Review of Fundamentals, Design Principles, Materials, and Applications.Biosensors · 2022Review
- Polymerase/Nicking Enzyme Powered Dual-template Multi-cycle G-Triplex Machine for HIV-1 Determination.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- The perspectives of biomarker-based electrochemical immunosensors, artificial intelligence and the Internet of Medical Things toward COVID-19 diagnosis and management.Materials today. Chemistry · 2021Review
- Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases.Biosensors & bioelectronics · 2021Review
- Aspects of Point-of-Care Diagnostics for Personalized Health Wellness.International journal of nanomedicine · 2021Review
- Nano-enabled biosensing systems for intelligent healthcare: towards COVID-19 management.Materials today. Chemistry · 2020Review
- Biosensors for Epilepsy Management: State-of-Art and Future Aspects.Sensors (Basel, Switzerland) · 2019Review
- Point of Care Sensing Devices: Better Care for Everyone.Sensors (Basel, Switzerland) · 2018Article
- A sensitive electrochemical immunosensor for label-free detection of Zika-virus protein.Scientific reports · 2018Article
- Novel nanoformulation to mitigate co-effects of drugs of abuse and HIV-1 infection: towards the treatment of NeuroAIDS.Journal of neurovirology · 2017Article
- Electrochemical Biosensors for Early Stage Zika Diagnostics.Trends in biotechnology · 2017Review
- Advancements in nano-enabled therapeutics for neuroHIV management.International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Electrochemical monitoring-on-chip (E-MoC)-based approach for rapid assessment of human immunodeficiency virus (HIV)-infection in the presence of cocaine (Coc) and specific drugs namely i.e., tenofovir (Tef), rimcazole (RA) is demonstrated here, for the first time, using electrochemical impedance spectroscopy (EIS). An in-vitro primary human astrocytes (HA) model was developed using a cultureware chip (CC, used for E-MoC) for HIV-infection, Coc exposure and treatment with anti-HIV drug i.e., Tef, and Coc antagonist i.e., RA. The charge transfer resistance (Rct) value of each CC well varies with respect to infection and treatment demonstrated highly responsive sensitivity of developed chip. The results of E-MoC, a proof-of-the concept, suggested that HIV-infection progression due to Coc ingestion and therapeutic effects of highly specific drugs are measurable on the basis of cell electrophysiology. Though, this work needs various molecular biology-based optimizations to promote this technology as an analytical tool for the rapid assessment of HIV-infection in a patient to manage HIV diseases for timely diagnosis. The presented study is based on using CNS cells and efforts are being made to perform this method using peripheral cells such as monocytes derived dendritic cells.
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Registered trials
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