Evidence map›Paper›PMID 27419865›Full record

ArticleCell2016

The Troubled Touch of Autism.

Alexander H Tuttle, Victoria B Bartsch, Mark J Zylka

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander H TuttleDepartment of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Victoria B BartschDepartment of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Mark J ZylkaDepartment of Cell Biology and Physiology, UNC Neuroscience Center, The Carolina Institute for Developmental Disabilities, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: zylka@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

The Elongation Hypothesis of AutismDP1ES024088 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2013 to 2017
$3.8M
Epigenetic Regulation of Ube3a as a Treatment for Angelman SyndromeR01MH093372 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PHILPOT, BENJAMIN D, ZYLKA, MARK J. · 2012 to 2016
$3.2M
Lipid kinase regulation of pain signaling and sensitizationR01NS081127 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2013 to 2017
$1.6M
NIEHS NIH HHS DP1 ES024088NIMH NIH HHS R01 MH093372NINDS NIH HHS R01 NS081127
6 · The paper itself

Abstract

A study finds that deficits in touch-sensing somatosensory neurons contribute to social interaction and anxiety phenotypes in mouse models of autism and Rett syndrome. These findings suggest that some core symptoms of autism might originate from aberrant development or function of the peripheral nervous system.

Indexed as

AnimalsAutistic DisorderDisease Models, AnimalMethyl-CpG-Binding Protein 2MiceRett SyndromeTouchMethyl-CpG-Binding Protein 2

Identifiers

PMID27419865
PMCPMC5461061
OpenAlexW2466878048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.