Evidence map›Paper›PMID 27419812›Full record

Trial reportSexually transmitted diseases2016

Perceived Risk Among Human Immunodeficiency Virus Serodiscordant Couples in East Africa Taking Oral Pre-Exposure Prophylaxis.

Jennifer J Carroll, Renee Heffron, Nelly Mugo, Kenneth Ngure, Patrick Ndase, Stephen Asiimwe, Connie Celum, Jared M Baeten

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Sexually transmitted diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04772469 (Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04772469 nacompletednot on this mapstarted 2021, after this paper: background citation

Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men

TypeinterventionalSponsorUniversity of California, San FranciscoRan2021 to 2023Enrolled934ConditionsHuman Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, HIV Infections, Sexually Transmitted Diseases, ViralArmsProvision of multiple self-tests, Small monetary incentives, Use of SMS/text reminders to motivate adherence to ART or PrEP
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jennifer J CarrollFrom the *Department of Epidemiology, †Department of Anthropology, ‡Department of Global Health, University of Washington, Seattle, WA; §Kenya Medical Research Institute; ‖Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya; ¶International Clinical Research Center, University of Washington, Seattle, WA; **Kabwohe Clinical Research Center, Kabwohe, Uganda; ††Department of Medicine, University of Washington, Seattle, WA.
Renee Heffron
Nelly Mugo
Kenneth Ngure
Patrick Ndase
Stephen Asiimwe
Connie Celum
Jared M Baeten
Kenya Medical Research Institute · KEJomo Kenyatta University of Agriculture and Technology · KEUniversity of Washington · US

Funding

Optimizing Antiretroviral-Based HIV Prevention for HIV Serodiscordant CouplesR01MH095507 · NIMH · UNIVERSITY OF WASHINGTON · PI BAETEN, JARED · 2011 to 2020
$6.1M
NIMH NIH HHS R01 MH095507
6 · The paper itself

Abstract

objectivesPerceived risk of human immunodeficiency virus (HIV) infection is thought to drive low adherence in pre-exposure prophylaxis (PrEP) trials. We explored the level of perceived risk of incident HIV infection in the Partners PrEP Study, in which adherence was generally high.

methodsA cross-sectional questionnaire assessed perceived risk of HIV at 12 months after enrollment. Logistic regression was used to analyze the relationship between perceived risk and other demographic and behavioral variables.

resultsThree thousand two hundred twenty-six couples from the Partners PrEP Study were included in this analysis. Only 15.4% of participants reported high or moderate perceived risk. Participants at high risk of acquiring HIV were slightly more likely to report high perceived risk (odds ratio, 1.60; 95% confidence interval, 1.30-1.95; P < 0.001); nevertheless, only 20% of participants with high-risk reported high perceived risk.

conclusionsParticipants reported low perceived risk of HIV but were adherent to PrEP. Perceptions of risk are likely socially determined and more complex than Likert scale questionnaires capture.

Indexed as

AdolescentAdultAnti-HIV AgentsCross-Sectional StudiesFemaleHeterosexualityHIV InfectionsHIV SeronegativityHumansKenyaMaleMedication AdherencePerceptionPre-Exposure ProphylaxisRiskSexual PartnersAnti-HIV AgentsTenofovir

Identifiers

PMID27419812
PMCPMC4948939
OpenAlexW2469564026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.