Evidence map›Paper›PMID 27419805›Full record

ArticleJournal of cellular and molecular medicine2016

Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK/mTOR pathway.

Liang Ji, Le Li, Fengzhi Qu, Guangquan Zhang, Yongwei Wang, Xuewei Bai, Shangha Pan, Dongbo Xue, Gang Wang, Bei Sun

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04760847 (Intermittent Fasting as a Primary Means for Improving Quality of Life for Acute and Chronic Pancreatitis), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04760847 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Intermittent Fasting as a Primary Means for Improving Quality of Life for Acute and Chronic Pancreatitis

TypeinterventionalSponsorH. Lee Moffitt Cancer Center and Research InstituteRan2026 to 2026Enrolled64ConditionsPancreatitis, Pancreatitis, Acute, Pancreatitis, Chronic, Pancreas DiseaseArmsIntermittent Fasting, No intermittent fasting
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  13. The role of autophagy in pancreatic diseases.Frontiers in pharmacology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Liang JiDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Le LiDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Fengzhi QuDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Guangquan ZhangDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yongwei WangDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xuewei BaiDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Shangha PanCentral Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Dongbo XueDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Gang WangDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Bei SunDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we have shown that hydrogen sulphide (H

Indexed as

Disease ProgressionAlkynesAMP-Activated Protein KinasesAnimalsAutophagyCell LineGlycineHydrogen SulfideLysosomesMalePancreatitisPhagosomesRats, WistarSignal TransductionTOR Serine-Threonine KinasesTrypsinogenAlkynesAMP-Activated Protein KinasesGlycineHydrogen SulfidepropargylglycineTOR Serine-Threonine KinasesTrypsinogenacute pancreatitisAMPKhydrogen sulphideimpaired autophagymTOR

Identifiers

PMID27419805
PMCPMC5134374
OpenAlexW2474601986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.