Evidence map›Paper›PMID 27419803›Full record

ArticleAlcoholism, clinical and experimental research2016

Effects of Age and Acute Moderate Alcohol Administration on Electrophysiological Correlates of Working Memory Maintenance.

Jeff Boissoneault, Ian Frazier, Ben Lewis, Sara Jo Nixon

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jeff BoissoneaultDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida.
Ian FrazierDepartment of Psychology, University of Florida, Gainesville, Florida.
Ben LewisDepartment of Psychiatry, University of Florida, Gainesville, Florida.
Sara Jo NixonDepartment of Psychology, University of Florida, Gainesville, Florida.
University of Florida · US

Funding

Neurocognition and Performance after Moderate Drinking in Older AdultsR01AA019802 · NIAAA · UNIVERSITY OF FLORIDA · PI NIXON, SARA JO · 2010 to 2012
$1.4M
Neurophysiological Correlates of Moderate Alcohol Use in Older Adults.F31AA019862 · NIAAA · UNIVERSITY OF FLORIDA · PI BOISSONEAULT, JEFFREY B · 2010 to 2011
$63k
NIAAA NIH HHS F31 AA019862NIAAA NIH HHS R01 AA019802
6 · The paper itself

Abstract

backgroundPrevious studies suggest older adults may be differentially susceptible to the acute neurobehavioral effects of moderate alcohol intake. To our knowledge, no studies have addressed acute moderate alcohol effects on the electrophysiological correlates of working memory in younger and older social drinkers. This study characterized alcohol-related effects on frontal theta (FTP) and posterior alpha power (PAP) associated with maintenance of visual information during a working memory task.

methodsOlder (55 to 70 years of age; n = 51, 29 women) and younger (25 to 35 years of age; n = 70, 39 women) community-dwelling moderate drinkers were recruited for this study. Participants were given either placebo or an active dose targeting breath alcohol concentrations (BrACs) of 0.04 or 0.065 g/dl. Following absorption, participants completed a visual working memory task assessing cue recognition following a 9-s delay. FTP and PAP were determined via Fourier transformation and subjected to 2 (age group) × 3 (dose) × 2 (repeated: working memory task condition) mixed models analysis.

resultsIn addition to expected age-related reductions in PAP, a significant age group × dose interaction was detected for PAP such that 0.04 g/dl dose level was associated with greater PAP in younger adults but lower PAP in their older counterparts. PAP was lower in older versus younger adults at both active doses. Further mixed models revealed a significant negative association between PAP and working memory efficiency for older adults. No effects of age, dose, or their interaction were noted for FTP.

conclusionsResults bolster the small but growing body of evidence that older adults exhibit differential sensitivity to the neurobehavioral effects of moderate alcohol use. Given the theoretical role of PAP in attentional and working memory function, these findings shed light on the attentional mechanisms underlying effects of acute moderate alcohol on working memory efficiency in older adults.

Indexed as

AdultAgedAgingAlcohol DrinkingBreath TestsCross-Sectional StudiesDouble-Blind MethodElectrophysiological PhenomenaEthanolFemaleHumansMaleMemory, Short-TermMiddle AgedPhotic StimulationPsychomotor PerformanceEthanolAgingAlcoholAlphaModerate DrinkingThetaWorking Memory

Identifiers

PMID27419803
PMCPMC5009001
OpenAlexW2475360938

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.