Evidence map›Paper›PMID 27419666›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.

David Karasik, Serkalem Demissie, Yanhua Zhou, Darlene Lu, Kerry E Broe, Mary L Bouxsein, L Adrienne Cupples, Douglas P Kiel

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Augmenting Osteoporosis Imaging with Machine Learning.Current osteoporosis reports · 2021
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Choose your mother wisely: the familial resemblance of bone adaptation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Regulatory SNP ofFrontiers in genetics · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

David KarasikInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Serkalem DemissieBiostatistics, Boston University School of Public Health, Boston, MA, USA.
Yanhua ZhouBiostatistics, Boston University School of Public Health, Boston, MA, USA.
Darlene LuBiostatistics, Boston University School of Public Health, Boston, MA, USA.
Kerry E BroeInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Mary L BouxseinCenter for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA, USA.
L Adrienne CupplesInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Kingston University · USBeth Israel Deaconess Medical Center · USBoston University · USDeaconess Hospital · USExelis (United States) · USFramingham Heart Study · USHebrew SeniorLife · US

Funding

The Gut Microbiome and Bone MicroarchitectureR01AR061445 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI KIEL, DOUGLAS P. · 2012 to 2021
$8.9M
NIAMS NIH HHS R01 AR061445
6 · The paper itself

Abstract

High-resolution peripheral quantitative computed tomography (HR-pQCT) measures bone microarchitecture and volumetric bone mineral density (vBMD), important risk factors for osteoporotic fractures. We estimated the heritability (h

Indexed as

Absorptiometry, PhotonAgedBone and BonesBone DensityFamilyFemaleHumansInheritance PatternsMaleQuantitative Trait, HeritableTomography, X-Ray ComputedBONE QCT/MICRO-CTCORTICAL POROSITYGENERAL POPULATION STUDIESGENETIC EPIDEMIOLOGICAL STUDYHERITABILITY

Identifiers

PMID27419666
PMCPMC5310688
OpenAlexW2491104035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.