Evidence map›Paper›PMID 27419615›Full record

ArticleJournal of the mechanical behavior of biomedical materials2016

Design and verification of a shape memory polymer peripheral occlusion device.

Todd L Landsman, Ruth L Bush, Alan Glowczwski, John Horn, Staci L Jessen, Ethan Ungchusri, Katelin Diguette, Harrison R Smith, Sayyeda M Hasan, Daniel Nash and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Article
  3. Initial Clinical Experience with Shape Memory Polymer Plugs for Various Venous Embolization.Interventional radiology (Higashimatsuyama-shi (Japan) · 2026
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  8. Development of Biopsy Tract Sealants Based on Shape Memory Polymer Foams.Biomedical materials & devices (New York, N.Y.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Todd L LandsmanDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
Ruth L BushCollege of Medicine, Texas A&M University Health Science Center, MS 1359, 8447 State Highway 47, HPEB 3060, Bryan, TX 77807-3260, USA.
Alan GlowczwskiTexas A&M Institute for Preclinical Studies, Texas A&M University, MS 4478, College Station, TX 77845-4478, USA.
John HornDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
Staci L JessenDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
Ethan UngchusriCollege of Medicine, Texas A&M University Health Science Center, MS 1359, 8447 State Highway 47, HPEB 3060, Bryan, TX 77807-3260, USA.
Katelin DiguetteDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
Harrison R SmithDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
Sayyeda M HasanDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA.
Daniel NashMaverick Regional Anesthesia Education, LLC, 10592 County Road 175, Iola, TX 77861, USA.
Fred J ClubbDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA; Department of Veterinary Pathobiology, Cardiovascular Pathology Laboratory, College of Veterinary Medicine, Texas A&M University, MS 4467, College Station, TX 77843-4467, USA.
Duncan J MaitlandDepartment of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843-3120, USA. Electronic address: djmaitland@tamu.edu.
Texas A&M University · USMaverick (United States) · USTexas A&M Health Science Center · US

Funding

Shape Memory Polymer Devices for Treating StrokeR01EB000462 · NIBIB · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI MAITLAND, DUNCAN J · 2002 to 2012
$12.5M
Shape Memory Polymer Vascular Occlusion Device for the Treatment of Venous Insufficiency Phase IIR44EB022016 · NIBIB · SHAPE MEMORY MEDICAL INC. · PI LANDSMAN, TODD · 2016 to 2017
$2.3M
Shape Memory Polymer Foam Vascular Occlusion Device for the Treatment of Chronic Venous InsufficiencyR43EB022016 · NIBIB · SHAPE MEMORY MEDICAL INC. · PI LANDSMAN, TODD · 2015 to 2015
$225k
NIBIB NIH HHS R01 EB000462NIBIB NIH HHS R43 EB022016NIBIB NIH HHS R44 EB022016
6 · The paper itself

Abstract

Shape memory polymer foams have been previously investigated for their safety and efficacy in treating a porcine aneurysm model. Their biocompatibility, rapid thrombus formation, and ability for endovascular catheter-based delivery to a variety of vascular beds makes these foams ideal candidates for use in numerous embolic applications, particularly within the peripheral vasculature. This study sought to investigate the material properties, safety, and efficacy of a shape memory polymer peripheral embolization device in vitro. The material characteristics of the device were analyzed to show tunability of the glass transition temperature (Tg) and the expansion rate of the polymer to ensure adequate time to deliver the device through a catheter prior to excessive foam expansion. Mechanical analysis and flow migration studies were performed to ensure minimal risk of vessel perforation and undesired thromboembolism upon device deployment. The efficacy of the device was verified by performing blood flow studies that established affinity for thrombus formation and blood penetration throughout the foam and by delivery of the device in an ultrasound phantom that demonstrated flow stagnation and diversion of flow to collateral pathways.

Indexed as

AneurysmAnimalsBiocompatible MaterialsEmbolization, TherapeuticPolymersSwineTransition TemperatureBiocompatible MaterialsPolymersEmbolizationPelvic congestion syndromeShape memory polymerVaricoceleVaricose veins

Identifiers

PMID27419615
PMCPMC5508979
OpenAlexW2467179530

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.