ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017
Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Bone age assessment with various machine learning techniques: A systematic literature review and meta-analysis.PloS one · 2019Pooled it
- Peak bone mass development in U.S. females with varied physical activity patterns: a longitudinal view using three maturational clocks.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Ancestry estimation: Methodological evolution and forensic implications.Forensic science, medicine, and pathology · 2026Review
- Independence of the body composition index from nutritional status affecting bone maturation.Pediatric research · 2026Article
- Genetic and epidemiologic assessment of mandibular cortical indices and bone mineral density in peripubertal children: the Generation R study.Clinical oral investigations · 2025Article
- Associations of fetal and infant growth with pubertal timing.Archives of disease in childhood · 2025Article
- Association between sex hormones and bone age in boys aged 9-18 years from China.Journal of cellular and molecular medicine · 2024Article
- CYP11B1 variants influence skeletal maturation via alternative splicing.Communications biology · 2021Article
- Dual-energy X-ray absorptiometry bone densitometry in pediatrics: a practical review and update.Pediatric radiology · 2021Review
- Factors affecting bone maturation in Chinese girls aged 4-8 years with isolated premature thelarche.BMC pediatrics · 2020Article
- Association between Insulin-Like Growth Factor-1 and Relative Skeletal Maturation: A Retrospective Cohort Study of Short Children and Adolescents.BioMed research international · 2020Article
- Using stable isotope tracers to study bone metabolism in children.The Journal of physiology · 2019Review
- Early Maturity as the New Normal: A Century-long Study of Bone Age.Clinical orthopaedics and related research · 2018Observational
- Adaptation of Bone to Mechanical Strain-Reply.JAMA pediatrics · 2018Article
- Association Between Linear Growth and Bone Accrual in a Diverse Cohort of Children and Adolescents.JAMA pediatrics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
More rapid skeletal maturation in African-American (AA) children is recognized and generally attributed to an increased prevalence of obesity. The objective of the present study was to evaluate the effects of population ancestry on relative skeletal maturation in healthy, non-obese children and adolescents, accounting for body composition and sexual maturation. To do this, we leveraged a multiethnic, mixed-longitudinal study with annual assessments for up to 7 years (The Bone Mineral Density in Childhood Study and its ancillary cohort) conducted at five US clinical centers. Participants included 1592 children, skeletally immature (45% females, 19% AA) who were aged 5 to 17 years at study entry. The primary outcome measure was relative skeletal maturation as assessed by hand-wrist radiograph. Additional covariates measured included anthropometrics, body composition by dual-energy X-ray absorptiometry (DXA), and Tanner stage of sexual maturation. Using mixed effects longitudinal models, without covariates, advancement in relative skeletal maturation was noted in self-reported AA girls (∼0.33 years, p < 0.001) and boys (∼0.43 years, p < 0.001). Boys and girls of all ancestry groups showed independent positive associations of height, lean mass, fat mass, and puberty with relative skeletal maturation. The effect of ancestry was attenuated but persistent after accounting for covariates: for girls, 0.19 years (ancestry by self-report, p = 0.02) or 0.29 years (ancestry by admixture, p = 0.004); and for boys, 0.20 years (ancestry by self-report, p = 0.004), or 0.29 years (ancestry by admixture, p = 0.004). In summary, we conclude that advancement in relative skeletal maturation was associated with AA ancestry in healthy, non-obese children, independent of growth, body composition, and puberty. Further research into the mechanisms underlying this observation may provide insights into the regulation of skeletal maturation. © 2016 American Society for Bone and Mineral Research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.