Evidence map›Paper›PMID 27419190›Full record

ArticleOpen forum infectious diseases2016

Therapeutic Trial of Rifabutin After Rifampicin-Associated DRESS Syndrome in Tuberculosis-Human Immunodeficiency Virus Coinfected Patients.

Rannakoe J Lehloenya, Sipho Dlamini, Rudzani Muloiwa, Betty Kakande, Mzudumile R Ngwanya, Gail Todd, Keertan Dheda

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Delabeling Delayed Drug Hypersensitivity: How Far Can You Safely Go?The journal of allergy and clinical immunology. In practice · 2020
    Article
  8. Drug hypersensitivity in HIV infection.Current opinion in allergy and clinical immunology · 2019
    Review
  9. Article
  10. AdDRESSing T-cell responses to antituberculous drugs.The British journal of dermatology · 2017
    Article
  11. Safety of Rifabutin in patients with rifampicin-induced thrombocytopenia.Lung India : official organ of Indian Chest Society
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rannakoe J LehloenyaDivision of Dermatology; Lung Infection and Immunity Unit.
Sipho DlaminiDivision of Infectious Disease and HIV Medicine, Department of Medicine.
Rudzani MuloiwaDepartment of Paediatrics and Child Health , University of Cape Town , South Africa.
Betty KakandeDivision of Dermatology.
Mzudumile R NgwanyaDivision of Dermatology.
Gail ToddDivision of Dermatology.
Keertan DhedaLung Infection and Immunity Unit.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.

Indexed as

alternativerifabutinrifampicin-associated drug eruptiontuberculosis HIV coinfection

Identifiers

PMID27419190
PMCPMC4942758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.