Evidence map›Paper›PMID 27419081›Full record

ArticleJournal of traditional and complementary medicine2016

Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial.

Zahra Naderi, Hassan Mozaffari-Khosravi, Ali Dehghan, Azadeh Nadjarzadeh, Hassan Fallah Huseini

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional and complementary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
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  5. Trial
  6. A Randomized Placebo-Controlled Dose-Response Trial of MuvzDrug design, development and therapy · 2025
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  17. Ginger (Antioxidants (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Review
  20. Ingredients of a Natural Oral Nutritional Supplement and Their Role in the Treatment of Osteoarthritis.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Zahra NaderiDepartment of Nutrition, Faculty of Health, Yazd University of Medical Sciences, Yazd, Iran.
Hassan Mozaffari-KhosraviDepartment of Nutrition, Faculty of Health, Yazd University of Medical Sciences, Yazd, Iran.
Ali DehghanDepartment of Internal Medicine, Shahid Sadoughi Hospital, Yazd University of Medical Sciences, Yazd, Iran.
Azadeh NadjarzadehDepartment of Nutrition, Faculty of Health, Yazd University of Medical Sciences, Yazd, Iran.
Hassan Fallah HuseiniDepartment of Pharmacology and Applied Medicine, Institute of Medical Plants, Iranian Academic Center for Education Culture & Research (ACECR), Karaj, Iran.
Yazd University · IRAcademic Center for Education, Culture and Research · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is limited evidence that ginger ( shēng jiāng) powder consumption can relieve pain and inflammation because of its special phytochemical properties. This study is aimed at investigating the effect of ginger powder supplementation on some inflammatory markers in patients suffering from knee osteoarthritis. This is a double-blind randomized placebo-controlled clinical trial with a follow-up period of 3 months that was conducted on 120 outpatients with moderately painful knee osteoarthritis. Patients were randomly divided up into two groups: ginger group (GG) or placebo group (PG). Both groups received two identical capsules on a daily basis for 3 months. Each ginger capsule contained 500 mg of ginger powder; the placebo capsules had 500 mg of starch in them. Serum samples were collected prior to and after the intervention and were stored at -70 °C until the end of the study. Serum concentration of nitric oxide (NO) and hs-C reactive protein (hs-CRP) were measured using enzyme-linked immunosorbent assay kits. There was no significant difference between the two groups in terms of inflammatory markers (i.e., NO and hs-CRP) prior to the intervention. However, after 3 months of supplementation, serum concentration of NO and hs-CRP decreased in the GG. After 12 weeks, the concentration of these markers declined more in the GG than in the PG. Ginger powder supplementation at a dose of 1 g/d can reduce inflammatory markers in patients with knee osteoarthritis, and it thus can be recommended as a suitable supplement for these patients.

Indexed as

C-reactive proteinElderlyGingerNitric oxideOsteoarthritis

Identifiers

PMID27419081
PMCPMC4936657
OpenAlexW2088866084

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.