ArticleJournal of clinical & translational endocrinology2016
High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial.
Article in Journal of clinical & translational endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 82 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High-Dose Vitamin D and Antimicrobial Peptide Expression in Lung Failure
The Association of Vitamin D Supplementation With the Outcome in Critically Ill Children
Vitamin D Supplementation and Covid-19: a Randomised, Double- Blind, Controlled Study
The Role of Vitamin D3 Supplementation in Advanced Cancer Patients With Pain
Who cites it
82 citing papers in PubMed, 14 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- Vitamin D supplementation and mortality among critically ill adults: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Vitamin D supplementation in critically ill patients: a meta-analysis.Frontiers in nutrition · 2025Pooled it
- Effects of different vitamins on individuals with septic shock: a Bayesian NMA of RCTs.Frontiers in nutrition · 2025Pooled it
- Has a High Dose of Vitamin D3 Impacted Health Conditions in Older Adults?-A Systematic Review and Meta-Analysis Focusing on Dose 100,000 IU.Nutrients · 2024Pooled it
- The effects of vitamin D on all-cause mortality in different diseases: an evidence-map and umbrella review of 116 randomized controlled trials.Frontiers in nutrition · 2023Pooled it
- Does vitamin D supplementation reduce COVID-19 severity?: a systematic review.QJM : monthly journal of the Association of Physicians · 2022Pooled it
- Administration of vitamin D and its metabolites in critically ill adult patients: an updated systematic review with meta-analysis of randomized controlled trials.Critical care (London, England) · 2022Pooled it
- High Dose Vitamin D3 Supplementation Is Not Associated With Lower Mortality in Critically Ill Patients: A Meta-Analysis of Randomized Control Trials.Frontiers in nutrition · 2022Pooled it
- Pooled it
- The Effect of Vitamin D Supplementation on Clinical Outcomes for Critically Ill Patients: A Systemic Review and Meta-Analysis of Randomized Clinical Trials.Frontiers in nutrition · 2021Pooled it
- Vitamin D supplementation and the outcomes of critically ill adult patients: a systematic review and meta-analysis of randomized controlled trials.Scientific reports · 2020Pooled it
- Pooled it
- Pooled it
- Vitamin D deficiency in critically ill children: a systematic review and meta-analysis.Critical care (London, England) · 2017Pooled it
- Effect of preoperative vitamin D on postoperative atrial fibrillation incidence after coronary artery bypass grafting.General thoracic and cardiovascular surgery · 2024Trial
- A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study).BMC pediatrics · 2023Trial
- Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2022Trial
- Early High-Dose Vitamin DThe New England journal of medicine · 2019Trial
- Oxidative stress in critically ill ventilated adults: effects of vitamin DEuropean journal of clinical nutrition · 2018Trial
- High-Dose Vitamin DJPEN. Journal of parenteral and enteral nutrition · 2018Trial
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThere is a high prevalence of vitamin D deficiency in the critically ill patient population. Several intensive care unit studies have demonstrated an association between vitamin D deficiency [25-hydroxyvitamin D (25(OH)D) < 20 ng/mL] and increased hospital length of stay (LOS), readmission rate, sepsis and mortality. MATERIAL AND
methodsPilot, double blind randomized control trial conducted on mechanically ventilated adult ICU patients. Subjects were administered either placebo, 50,000 IU vitamin D
resultsA total of 31 subjects were enrolled with 13 (43%) being vitamin D deficient at entry (25(OH)D levels < 20 ng/mL). The 250,000 IU and 500,000 IU vitamin D
conclusionsIn this pilot study, high-dose vitamin D3 safely increased plasma 25(OH)D concentrations into the sufficient range and was associated with decreased hospital length of stay without altering other clinical outcomes. CLINICAL
trial registrationwww.clinicaltrials.gov (NCT01372995).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.