Evidence map›Paper›PMID 27419057›Full record

ArticleFEBS open bio2016

TAK1 deficiency in dendritic cells inhibits adaptive immunity in SRBC-immunized C57BL/6 mice.

Yao Pan, Zhiming Lei, Xuetao Wei, Weidong Hao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yao PanDepartment of ToxicologySchool of Public HealthPeking UniversityBeijingChina; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food SafetyBeijingChina.
Zhiming LeiDepartment of ToxicologySchool of Public HealthPeking UniversityBeijingChina; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food SafetyBeijingChina.
Xuetao WeiDepartment of ToxicologySchool of Public HealthPeking UniversityBeijingChina; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food SafetyBeijingChina.
Weidong HaoDepartment of ToxicologySchool of Public HealthPeking UniversityBeijingChina; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food SafetyBeijingChina.
China National Center for Food Safety Risk Assessment · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are important in the initiation of primary T-cell responses, while transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a critical regulator of DC survival and homeostasis. This study evaluated the T-cell dependent antibody response (TDAR) to sheep red blood cells (SRBC) on a DC-specific TAK1-deficient mice model. The results showed that TAK1 deficiency in DCs significantly suppressed the humoral and cellular immune response in mice. DC-specific TAK1 deletion impaired splenic T-cell population and conventional DCs, abolished the cytokine production of splenic T cells and down-regulated some functional gene expression in the spleen. Collectively, this study suggests that TAK1 plays an essential role in the development of the humoral immune response.

Indexed as

dendritic cellssheep red blood cellsT‐cell dependent antigen responsetransforming growth factor‐β‐activated kinase 1

Identifiers

PMID27419057
PMCPMC4887970
OpenAlexW2313579375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.